Clinical Efficacy of Topical Diquafosol Tetrasodium after Laser Epithelial Keratomileusis. |
Min Kyo Kim, Hyun Kyo Jeong, Ji Min Ahn, Hong Seok Kim |
1Siloam Eye Hospital, Seoul, Korea. curiokim@naver.com 2The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea. |
라섹 수술 후 3% 디쿠아포솔나트륨 점안액 사용의 임상적 유용성 |
김민교1,2⋅정현교1,2⋅안지민1⋅김홍석1 |
실로암안과병원1, 연세대학교 의과대학 안과학교실 시기능개발연구소2 |
Received: 13 March 2015 • Revised: 29 April 2015 • Accepted: 6 July 2015 |
Abstract |
PURPOSE To evaluate the clinical effectiveness of topical diquafosol tetrasodium (DQS) after laser epithelial keratomileusis (LASEK). METHODS: This randomized prospective study included 97 eyes of 49 patients who were scheduled for LASEK. Patients in the DQS group used both 0.3% sodium hyaluronate and 3% DQS for 3 months after surgery while patients in the control group used only 0.3% sodium hyaluronate. Corneal staining score, tear film break-up time (TF-BUT), Schirmer test and ocular surface disease index (OSDI) were evaluated before surgery and 2, 4, 8, 12 and 16 weeks after surgery. RESULTS: There was no significant difference in visual acuity, spherical equivalent and corneal haziness between the 2 groups after surgery. Corneal staining score was significantly lower in the DQS group than in the control group 2 weeks after LASEK (p < 0.01) and increased in the control group after LASEK compared with the preoperative value (2 weeks after LASEK, p < 0.01), but decreased in the DQS group (12 and 16 weeks after LASEK, p < 0.05). TF-BUT was significantly higher in the DQS group than in the control group 2 to 16 weeks after LASEK (p < 0.01) and increased values were observed in the DQS group after LASEK compared with the preoperative value (4 to 16 weeks after LASEK, p < 0.05). The mean OSDI was significantly higher 4 to 16 weeks after LASEK in the control group than in the DQS group (p < 0.01). CONCLUSIONS: Subjective dry eye symptoms and objective markers were worse for 4 weeks after LASEK. The use of 3% DQS for 12 weeks after surgery improved these symptoms and markers with the effect lasting 16 weeks after LASEK. |
Key Words:
Diquafosol tetrasodium;Dry eye syndrome;LASEK;Refractive surgery |
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