J Korean Ophthalmol Soc > Volume 56(9); 2015 > Article
Journal of the Korean Ophthalmological Society 2015;56(9):1324-1330.
DOI: https://doi.org/10.3341/jkos.2015.56.9.1324    Published online September 15, 2015.
Clinical Efficacy of Topical Diquafosol Tetrasodium after Laser Epithelial Keratomileusis.
Min Kyo Kim, Hyun Kyo Jeong, Ji Min Ahn, Hong Seok Kim
1Siloam Eye Hospital, Seoul, Korea. curiokim@naver.com
2The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
라섹 수술 후 3% 디쿠아포솔나트륨 점안액 사용의 임상적 유용성
김민교1,2⋅정현교1,2⋅안지민1⋅김홍석1
실로암안과병원1, 연세대학교 의과대학 안과학교실 시기능개발연구소2
Received: 13 March 2015   • Revised: 29 April 2015   • Accepted: 6 July 2015
Abstract
PURPOSE
To evaluate the clinical effectiveness of topical diquafosol tetrasodium (DQS) after laser epithelial keratomileusis (LASEK). METHODS: This randomized prospective study included 97 eyes of 49 patients who were scheduled for LASEK. Patients in the DQS group used both 0.3% sodium hyaluronate and 3% DQS for 3 months after surgery while patients in the control group used only 0.3% sodium hyaluronate. Corneal staining score, tear film break-up time (TF-BUT), Schirmer test and ocular surface disease index (OSDI) were evaluated before surgery and 2, 4, 8, 12 and 16 weeks after surgery. RESULTS: There was no significant difference in visual acuity, spherical equivalent and corneal haziness between the 2 groups after surgery. Corneal staining score was significantly lower in the DQS group than in the control group 2 weeks after LASEK (p < 0.01) and increased in the control group after LASEK compared with the preoperative value (2 weeks after LASEK, p < 0.01), but decreased in the DQS group (12 and 16 weeks after LASEK, p < 0.05). TF-BUT was significantly higher in the DQS group than in the control group 2 to 16 weeks after LASEK (p < 0.01) and increased values were observed in the DQS group after LASEK compared with the preoperative value (4 to 16 weeks after LASEK, p < 0.05). The mean OSDI was significantly higher 4 to 16 weeks after LASEK in the control group than in the DQS group (p < 0.01). CONCLUSIONS: Subjective dry eye symptoms and objective markers were worse for 4 weeks after LASEK. The use of 3% DQS for 12 weeks after surgery improved these symptoms and markers with the effect lasting 16 weeks after LASEK.
Key Words: Diquafosol tetrasodium;Dry eye syndrome;LASEK;Refractive surgery


ABOUT
BROWSE ARTICLES
EDITORIAL POLICY
FOR CONTRIBUTORS
Editorial Office
SKY 1004 Building #701
50-1 Jungnim-ro, Jung-gu, Seoul 04508, Korea
Tel: +82-2-583-6520    Fax: +82-2-583-6521    E-mail: kos08@ophthalmology.org                

Copyright © 2024 by Korean Ophthalmological Society.

Developed in M2PI

Close layer
prev next