J Korean Ophthalmol Soc > Volume 56(9); 2015 > Article
Journal of the Korean Ophthalmological Society 2015;56(9):1408-1415.
DOI: https://doi.org/10.3341/jkos.2015.56.9.1408    Published online September 15, 2015.
Comparative Results of Trabeculectomy with Mitomycin C in Uveitic Glaucoma versus Primary Open-Angle Glaucoma.
Yeon Ho Lee, Hyun Ju Oh, Soon Cheol Cha
Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Korea. sccha@yumail.ac.kr
포도막염에 의한 녹내장과 원발개방각녹내장 환자에서 섬유주절제술의 성적 비교
영남대학교 의과대학 안과학교실
Received: 3 April 2015   • Revised: 15 May 2015   • Accepted: 21 July 2015
In this study we evaluated the long-term outcomes and prognostic factors of trabeculectomy with mitomycin C (MMC) in eyes with uveitic glaucoma (UG) compared with primary open-angle glaucoma (POAG). METHODS: We performed a retrospective chart review of 60 eyes with UG and 402 eyes with POAG that were followed up for at least 1 year after trabeculectomy with MMC between June 2000 and December 2012. The review included intraocular pressure (IOP), number of anti-glaucoma medications, and postoperative complications. Surgical success was analyzed using the Kaplan-Meier life-table method based on 2 definitions of successful IOP control with topical anti-glaucoma medications: Definition A (IOP < or = 15 mm Hg) and Definition B (IOP < or = 18 mm Hg). Risk factors for surgical failure of trabeculectomy were analyzed using the Cox proportional hazards model. RESULTS: Success rate at 5 years after trabeculectomy was lower in UG than in POAG (65.8% vs. 76.4%, Definition B), but without significant difference. However, UG had a significantly lower cumulative probability of success than POAG based on Kaplan-Meier survival curves (p = 0.049 and 0.044, respectively). Postoperative hypotony and hypotony maculopathy was more frequent in UG (p = 0.044 and 0.044, respectively). In UG, the Cox proportional hazards model showed postoperative shallow anterior chamber was associated with surgical failure in both Definition A and B. CONCLUSIONS: Long-term results of trabeculectomy with MMC in eyes with UG showed successful IOP control similar to POAG. Trabeculectomy with MMC is a reasonable surgical option for the management of UG.
Key Words: Primary open angle glaucoma;Trabeculectomy;Uveitic glaucoma

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