J Korean Ophthalmol Soc > Volume 56(11); 2015 > Article
Journal of the Korean Ophthalmological Society 2015;56(11):1653-1660.
DOI: https://doi.org/10.3341/jkos.2015.56.11.1653    Published online November 15, 2015.
Long-Term Outcomes after Cryotherapy for Conjunctival Mucosa-Associated Lymphoid Tissue Lymphomas.
Si Eun Lee, Keun Hae Kim
Department of Ophthalmology, Catholic University of Daegu School of Medicine, Daegu, Korea. kimkh@cu.ac.kr
결막의 점막연관 림프조직 림프종에서 냉동요법의 장기 결과
이시은⋅김근해
대구가톨릭대학교 의과대학 안과학교실
Correspondence:  Keun Hae Kim,
Email: kimkh@cu.ac.kr
Received: 22 May 2015   • Revised: 15 June 2015   • Accepted: 4 September 2015
Abstract
PURPOSE
To evaluate long-term outcomes after cryotherapy for conjunctival mucosa-associated lymphoid tissue (MALT) lymphomas. METHODS: We retrospectively analyzed 11 eyes of 8 patients who underwent cryotherapy with a confirmed histopathological diagnosis of conjunctival MALT lymphoma between January 2006 and December 2010 and were followed up for at least a year. RESULTS: The mean patient age was 36.8 years and the average follow-up was 4.1 years. Complete remission was achieved in 3 patients (4 eyes) and recurrence occurred in 5 patients (7 eyes) after the first cryotherapy. After the third cryotherapy, complete remission was achieved in 2 patients (2 eyes) and recurrence occurred in 3 patients (5 eyes). Therefore, 3 patients (5 eyes) underwent radiotherapy and finally achieved complete remission. After cryotherapy, significant complications were not observed except mild symblepharon in 4 patients (6 eyes). CONCLUSIONS: Cryotherapy, although having a higher recurrence rate than radiotherapy, is a simple treatment modality with fewer complications for patients. In the conjunctival MALT lymphoma patients who cannot undergo radiotherapy, cryotherapy should be considered as an alternative treatment modality.
Key Words: Conjunctiva;Cryotherapy;Mucosa-associated lymphoid tissue (MALT) lymphoma


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