J Korean Ophthalmol Soc > Volume 53(9); 2012 > Article
Journal of the Korean Ophthalmological Society 2012;53(9):1231-1235.
DOI: https://doi.org/10.3341/jkos.2012.53.9.1231    Published online September 15, 2012.
The Effect of Mitomycin C Instillation after Silicone Intubation in Adult Partial Nasolacrimal Duct Obstruction.
Jin Gu Jeong, Min Ahn
1Department of Ophthalmology, Chonbuk National University Medical School, Jeonju, Korea. ahnmin@jbnu.ac.kr
2Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.
성인 코눈물관 부분폐쇄에서 실리콘관 삽입술 후 마이토마이신 점안의 효과
정진구1⋅안 민1,2
Department of Ophthalmology, Chonbuk National University Medical School1, Jeonju, Korea
Research Institute of Clinical Medicine of Chonbuk National University-
Biomedical Research Institute of Chonbuk National University Hospital2, Jeonju, Korea
Abstract
PURPOSE
To compare the result of mitomycin C (MMC) instillation after silicone intubation in partial nasolacrimal duct obstruction in adults according to duration of instillation. METHODS: An instillation of 0.04% MMC eyedrops was performed on 61 eyes of 38 patients diagnosed with partial nasolacrimal duct obstruction. The clinical result of patient groups, classified according to duration of MMC eyedrops instillation, was analyzed prospectively. The patients groups was as follows: no MMC eyedrop instillation (group A), 1 week of MMC instillation (group B), 2 weeks of MMC instillation (group C), and 3 weeks of MMC instillation (group D). RESULTS: Among all patients, 50 eyes (81.9%) showed improved symptoms. Fifteen eyes (71.4%) in group A, 8 eyes (72.7%) in group B, 13 eyes (86.7%) in group C and 14 eyes (100.0%) in group D had a successful outcome. The success rate was observed in groups D, C, B, and A, in descending order, which was statistically significant (p = 0.025). CONCLUSIONS: Silicone intubation is an effective treatment option for partial nasolacrimal duct obstruction in adults and MMC eyedrop instillation may improve silicone intubation results.
Key Words: Mitomycin-C;Nasolacrimal duct obstruction;Silicone intubation


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