Analysis of Clinical Effectiveness of Tafluprost by Ocular Pulse Amplitude.

Moon, Da Ru Chi; Ha, Seung Joo

doi:2013.54.2.303

J Korean Ophthalmol Soc > Volume 54(2); 2013 > Article

Original Article

Journal of the Korean Ophthalmological Society 2013;54(2):303-309.
DOI: https://doi.org/10.3341/jkos.2013.54.2.303 Published online February 28, 2013.

Analysis of Clinical Effectiveness of Tafluprost by Ocular Pulse Amplitude.

Da Ru Chi Moon, Seung Joo Ha

Department of Ophthalmology, Soonchunhyang University College of Medicine, Seoul, Korea. sjha@schmc.ac.kr

Ocular Pulse Amplitude를 이용한 타플루프로스트의 임상적 효과 분석

문다루치⋅하승주

Department of Ophthalmology, Soonchunhyang University College of Medicine, Seoul, Korea

Abstract

PURPOSE
To analyze the clinical effectiveness of tafluprost used in the treatment of glaucoma, using ocular pulse amplitude (OPA) measurements with dynamic contour tonometry (DCT). METHODS: Sixty patients (119 eyes) with normal tension glaucoma (NTG) or primary open angle glaucoma (POAG) treated with tafluprost or other eyedrops were investigated in the present study. Intraocular pressure (IOP) was measured with Goldmann applanation tonometry (GAT), and OPA was measured with DCT, before and after treatment, retrospectively. RESULTS: In 20 patients treated with tafluprost, IOP decreased from 17.1 mm Hg before treatment to 13.0 mm Hg 3 months after treatment (24.0% descent rate), and OPA decreased from 2.35 to 1.57 (33.2% descent rate). For 20 patients who switched from another monotherapy to tafluprost, IOP decreased from 15.7 mm Hg to 13.2 mm Hg from 15.7 mm Hg (15.3%) and OPA from 2.38 to 1.69 (27.7%). CONCLUSIONS: Tafluprost used to treat glaucoma has a large OPA and IOP lowering effect and, therefore can be applied to patients who have a large OPA with glaucoma progression in spite of well controlled IOP.

Key Words: Normal tension glaucoma;Ocular pulse amplitude;Primary open angle glaucoma;Tafloprost