Effect of Intravenous Methylprednisolone on Idiopathic Orbital Inflammation.

Chung, Seung Ah; Yoon, Jin SooK; Lee, Sang Yeul

doi:2010.51.10.1299

J Korean Ophthalmol Soc > Volume 51(10); 2010 > Article

Original Article

Journal of the Korean Ophthalmological Society 2010;51(10):1299-1304.
DOI: https://doi.org/10.3341/jkos.2010.51.10.1299 Published online October 15, 2010.

Effect of Intravenous Methylprednisolone on Idiopathic Orbital Inflammation.

Seung Ah Chung, Jin SooK Yoon, Sang Yeul Lee

¹Department of Ophthalmology, Myongji Hospital, Kwandong University College of Medicine, Goyang, Korea.
²The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea. sylee@yuhs.ac

비특이성안와염에서 고용량 부신피질호르몬 주사요법의 효과

정승아¹ㆍ윤진숙²ㆍ이상열²

Department of Ophthalmology, Myongji Hospital, Kwandong University College of Medicine¹, Goyang, Korea The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine², Seoul, Korea

Abstract

PURPOSE
To evaluate the efficacy of intravenous methylprednisolone pulse therapy in patients with idiopathic orbital inflammation. METHODS: Fifty-two patients who received three-day pulse methylprednisolone for acute severe swelling, loss of visual acuity, limitation of eye movement, diplopia, or pain were included in the present study. The lesions were divided into five subtypes using computed tomography or magnetic resonance imaging; anterior, lacrimal, myositic, diffuse and apical. A case diagnosed as sclerotic type was excluded. The response rate, recurrence rate and cure rate were assessed. RESULTS: The total response rate to intravenous methylprednisolone from all groups was 84.6%, with 100% in the anterior subtype and 71.4% in the diffuse subtype. During the mean follow-up period of 10.5 months, 15.9% of patients experienced a recurrence after a mean of 5.7 months. Overall, the cure rate was 71.2%. Recurrence was more common in the younger patients, and three of the seven patients with recurrence had myositic inflammation. CONCLUSIONS: Intravenous methylprednisolone was effective in patients with severe idiopathic orbital inflammation. However, combining other treatment modalities in patients with diffuse or myositic subtypes and in younger patients who show relatively low response or high recurrence is recommended.

Key Words: Idiopathic orbital inflammation;Methylprednisolone;Pseudotumor;Steroid