Acyclovir-induced Acute Renal Failure in a Patient With Suspected Acute Retinal Necrosis Syndrome.

Cho, Joon Hee; Jang, Joo Hyun; Lee, Dong Hun; Lee, Young Ki; Noh, Jung Woo; Bae, Ji Hyun; Kim, Ha Kyoung

doi:2010.51.11.1528

J Korean Ophthalmol Soc > Volume 51(11); 2010 > Article

Case Report

Journal of the Korean Ophthalmological Society 2010;51(11):1528-1531.
DOI: https://doi.org/10.3341/jkos.2010.51.11.1528 Published online November 15, 2010.

Acyclovir-induced Acute Renal Failure in a Patient With Suspected Acute Retinal Necrosis Syndrome.

Joon Hee Cho, Joo Hyun Jang, Dong Hun Lee, Young Ki Lee, Jung Woo Noh, Ji Hyun Bae, Ha Kyoung Kim

¹Department of Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. ophkim@hallym.or.kr
²Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

급성망막괴사증후군 의심 환자에서 항바이러스제 정맥주사 후 발생한 급성신부전 1 예

조준희¹ㆍ장주현²ㆍ이동훈²ㆍ이영기²ㆍ노정우²ㆍ배지현¹ㆍ김하경¹

Department of Ophthalmology¹, Internal Medicine², Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea

Abstract

PURPOSE
To report a case of acyclovir-induced acute renal failure (ARF) suspected as acute retinal necrosis syndrome. CASE SUMMARY: The authors report a 55-year-old male patient who presented with left eye visual disturbance due to suspected acute retinal necrosis syndrome. Non-oliguric ARF developed after the infusion of intravenous acyclovir (850 mg every 8 hours). The patient did not show any uremic symptoms or signs. The crystal was not discovered in the urine. After stopping the acyclovir infusion and hydration, acyclovir-induced ARF was reversed. CONCLUSIONS: Although possessing critical nephrotoxicity, acyclovir is a useful antiviral drug. Therefore, when using acyclovir, the importance of hydration and preventing acyclovir-induced ARF should be considered.

Key Words: Acute renal failure;Acute retinal necrosis syndrome;Acyclovir