| Comparison of the Effects Between Bevacizumab and Mitomycin C on the Survival of Fibroblasts. |
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Sin Hoo Kim, Jae Woo Kim |
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Department of Ophthalmology, Catholic University of Daegu College of Medicine, Daegu, Korea. jwkim@cu.ac.kr |
| 섬유아세포의 생존에 대한 베바시주맙과 마이토마이신 C의 효과 비교 |
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김신후⋅김재우 |
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Department of Ophthalmology, Catholic University of Daegu College of Medicine, Daegu, Korea |
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| Abstract |
PURPOSE
To compare the antiproliferative effects between bevacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF), and mitomycin C in human Tenon's capsule fibroblasts. METHODS: Primarily cultured human Tenon's capsule fibroblasts were exposed to 0, 25, 50, 100, and 200 microg/ml bevacizumab and mitomycin C, and incubated for 5 days. Cellular survival and production of nitric oxide were assessed by MTT assay and Griess assay, respectively. RESULTS: Bevacizumab showed antiproliferative effects only at high concentrations (200 microg/ml) and revealed much less effect on the cellular survival compared to mitomycin C. In addition, bevacizumab did not affect the production of nitric oxide. CONCLUSIONS: The antiproliferative effect of bevacizumab is much lower than mitomycin C in human Tenon's capsule fibroblasts. |
| Key Words:
Antiproliferation;Bevacizumab;Fibroblast;Mitomycin C |
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