Prophylactic Effects of a Fixed Dorsolamide/Timolol Combination on IOP Elevation before Intravitreal Anti-VEGF Injection.

Lim, Young Jin; Kim, Jong Myong; Han, Yong Seop; Chung, In Young; Park, Jong Moon

doi:2011.52.6.702

J Korean Ophthalmol Soc > Volume 52(6); 2011 > Article

Randomized Controlled Trial

Journal of the Korean Ophthalmological Society 2011;52(6):702-708.
DOI: https://doi.org/10.3341/jkos.2011.52.6.702 Published online June 16, 2011.

Prophylactic Effects of a Fixed Dorsolamide/Timolol Combination on IOP Elevation before Intravitreal Anti-VEGF Injection.

Young Jin Lim, Jong Myong Kim, Yong Seop Han, In Young Chung, Jong Moon Park

¹Department of Ophthalmology, Gyeongsang National University School of Medicine, Jinju, Korea. medcabin@hanmail.net
²Institute of Health Science, Gyeongsang National University, Jinju, Korea.

유리체강 내 항혈관내피세포성장인자 주입술 전의 예방적 안압강하제의 효과

임영진¹⋅김종명¹⋅한용섭¹⋅정인영^1,2⋅박종문^1,2

Department of Ophthalmology, Gyeongsang National University School of Medicine¹, Jinju, Korea Institute of Health Science, Gyeongsang National University², Jinju, Korea

Abstract

PURPOSE
The purpose of the present study was to investigate the prophylactic effects of a fixed combination of dorsolamide/timolol on intraocular pressure (IOP) elevation before intravitreal anti-VEGF injection. METHODS: A prospective, randomized clinical trial was conducted on 91 eyes of 91 patients undergoing intravitreal anti-VEGF injection. The eyes were randomly divided into 2 groups, the eyes which had used the fixed prophylactic dorsolamide/timolol combination (group 1, 58 eyes) and the eyes which had not used the combination (group 2, 15 eyes). The IOP was measured one hour and 5 minutes prior to the procedure, 5 minutes interval up to 30 minutes after the procedure and one hour, 1 day, 7 days, and one month after the procedure. The IOP changes were analyzed. RESULTS: The mean 5 minutes and 30 minutes postoperative IOPs were 14.12 +/- 4.18 mm Hg and 10.87 +/- 1.58 mm Hg in group 1 and 28.21 +/- 3.16 mm Hg and 17.48 +/- 2.34 mm Hg in group 2, respectively. After IVBI, the mean 5 min postoperative IOP was 12.17 +/- 1.13 mm Hg in group 1 and 27.12 +/- 3.35 mm Hg in group 2. After IVRI, the mean 5 minutes postoperative IOP was 15.98 +/- 4.14 mm Hg in group 1 and 25.19 +/- 1.04 mm Hg in group 2. CONCLUSIONS: Prophylactic use of a fixed dorsolamide/timolol combination before intravitreal anti-VEGF injection is an easy and safe method of preventing IOP elevation immediately after intravitreal injection of bevacizumab or ranibizumab.

Key Words: Bevacizumab;Dorsolamide;IOP;Ranibizumab;Timolol