| Preemptive Analgesic Effect of Topical NSAIDS in Postoperative Pain Relief after LASEK. |
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Se Kyung Kim, Jin Pyo Hong, Sang Min Nam, Kyoung Yul Seo |
1The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea. seoky@yuhs.ac
2Seyan Eye Center, Seoul, Korea.
3Department of Ophthalmology, Bundang CHA Hospital, CHA University, Seongnam, Korea. |
| 라섹 수술 후 통증에 대한 비스테로이드성 항염증 점안액의 선행 진통 효과 |
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김세경1⋅홍진표2⋅남상민3⋅서경률1 |
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The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine1, Seoul, Korea Seyan Eye Center2, Seoul, Korea Department of Ophthalmology, Bundang CHA Hospital, CHA University3, Seongnam, Korea |
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| Abstract |
PURPOSE
To assess the preemptive analgesic effect of topical NSAIDs (0.5% ketorolac tromethamine, Acular) as postoperative pain relief in patients undergoing LASEK. METHODS: A prospective, randomized, placebo-controlled, paired eye study was performed. Patients undergoing LASEK were randomized to receive 0.5% ketorolac in one eye and 0.3% ofloxacin (placebo) in the contralateral eye at 30 minutes, 20 minutes, or ten minutes prior to LASEK. Pain was assessed using a visual analog scale of 0 to 10 in each eye 6, 12, 24, 36, 48 and 72 hours after surgery. Patients were also asked to assess the levels of glare, tearing and irritation using a visual analog scale from 0 to 10. RESULTS: A total of 62 eyes from 31 patients were enrolled in the present study. The mean postoperative pain score in the NSAID group was significantly lower than that in the placebo group at postoperative hours 6 (2.35 versus 4.97), 12 (2.52 versus 5.16), and 24 (3.84 versus 4.94) (p < 0.05). The mean postoperative pain score after 36 and 48hours was also lower in the NSAID group than in the placebo group, but the differences were not statistically significant (p > 0.05). Patients reported significantly less tearing and irritation in the NSAID-administered eye compared to those in the placebo eye after LASEK (p < 0.05). CONCLUSIONS: Preemptive administration of topical NSAIDs before LASEK was effective in reducing acute postoperative pain. Preemptive analgesia with topical NSAIDs may be a valuable treatment option for controlling postoperative pain following ocular surgery. |
| Key Words:
LASEK;Nonsteroidal anti-inflammatory drug;Pain;Preemptive analgesia |
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