Effects of Mitomycin C on Eyelash-Regrowth in Epilated Rats.

Kim, Che Ron; Yoo, Woong Sun; Kim, Kyeong Hyun; Seo, Seong Wook

doi:2011.52.12.1501

J Korean Ophthalmol Soc > Volume 52(12); 2011 > Article

Original Article

Journal of the Korean Ophthalmological Society 2011;52(12):1501-1506.
DOI: https://doi.org/10.3341/jkos.2011.52.12.1501 Published online December 15, 2011.

Effects of Mitomycin C on Eyelash-Regrowth in Epilated Rats.

Che Ron Kim, Woong Sun Yoo, Kyeong Hyun Kim, Seong Wook Seo

¹Department of Ophthalmology, School of Medicine, Gyeongsang National University, Jinju, Korea. stramast@naver.com
²Gyeongsang Institute of Health Science, Gyeongsang National University, Jinju, Korea.

마이토마이신 C가 흰 쥐의 속눈썹 재성장에 미치는 영향

김체론¹⋅유웅선¹⋅김경현¹⋅서성욱^1,2

Department of Ophthalmology, School of Medicine, Gyeongsang National University¹, Jinju, Korea Gyeongsang Institute of Health Science, Gyeongsang National University², Jinju, Korea

Abstract

PURPOSE
The aim of the present study was to determine the effects of mitomycin C (MMC) on eyelash regrowth in rats. METHODS: Ten rats were subjected to bilateral eyelid epilation. One drop of 0.04% MMC solution and one drop of normal saline was then administered to the right and left eyelid, respectively. Three months post-epliation, the number of regrown eyelashes was counted, and a section of tissue from each eyelid was examined under light- and electron microscopies. RESULTS: The number of regrown long eyelashes was 1.0 +/- 0.81 on the right, and 12.5 +/- 1.08 on the left. The rate of regrowth was 7.35 +/- 5.55% on the right and 98.45 +/- 3.27% on the left. Histological examination revealed no significant differences between the right and left eyelids, except for the absence of any hair shafts in the follicles on the right. However, electron microscopy revealed mitochondrial damage in the follicles of the right eyelid. These changes were not observed in tissue from the left eyelid. CONCLUSIONS: The application of 0.04% MMC inhibited the regrowth of normal eyelashes in rats following simple epilation. These results suggest that MMC may be a novel therapy for replacing invasive surgery in trichiasis with no malpositioning.

Key Words: Eyelash;Mitomycin C;Trichiasis