Photodynamic Therapy of Choroidal Neovascularization in Age-Related Macular Degeneration with Verteporfin: An Analysis of 10 Years of Clinical Results.

Cho, Doo Young; Bae, So Hyun; Han, Jae Ryong; Kim, Ha Kyoung; Nam, Woo Ho

doi:2012.53.1.59

J Korean Ophthalmol Soc > Volume 53(1); 2012 > Article

Original Article

Journal of the Korean Ophthalmological Society 2012;53(1):59-67.
DOI: https://doi.org/10.3341/jkos.2012.53.1.59 Published online January 15, 2012.

Photodynamic Therapy of Choroidal Neovascularization in Age-Related Macular Degeneration with Verteporfin: An Analysis of 10 Years of Clinical Results.

Doo Young Cho, So Hyun Bae, Jae Ryong Han, Ha Kyoung Kim, Woo Ho Nam

¹Department of Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. wooho.nam@gmail.com
²Department of Ophthalmology, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

맥락막신생혈관을 동반한 삼출성 나이관련황반변성 환자에서 광역학치료 후 10년간의 경과관찰

조두영¹⋅배소현¹⋅한재룡²⋅김하경¹⋅남우호¹

Department of Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine¹, Seoul, Korea Department of Ophthalmology, Hangang Sacred Heart Hospital, Hallym University College of Medicine², Seoul, Korea

Abstract

PURPOSE
To analyze the long-term results of photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD). METHODS: The clinical data of patients treated with photodynamic therapy for exudative age-related macular degeneration between April 2000 and December 2000 were analyzed. Patients were followed-up for at least 10 years after PDT. RESULTS: Twenty-nine eyes of 29 patients were enrolled. Mean visual acuity on the logarithm of the minimum angle of resolution (log MAR) scale was 0.78 +/- 0.34 at baseline, 1.01 +/- 0.42 at 60 months, and 1.02 +/- 0.41 at 120 months. Predominantly classic, minimally classic, and occult without classic choroidal neovascularization was noted in 51.7%, 17.2%, and 31.1% of patients, respectively. Visual acuity was improved by 1 or more lines in 27.6% of patients and was unchanged in 20.7% of patients, while 51.7% of patients had lost 1 or more lines of visual acuity by 120 months. Baseline visual acuity and age were associated with the final visual prognosis (p < 0.05). Four patients developed neovascular AMD in the contralateral eye. CONCLUSIONS: PDT is safe and effective for neovascular AMD. However, AMD can recur at any time and thus patients should be followed-up for a long period of time.

Key Words: Age-related macular degeneration (AMD);Choroidal neovascularization (CNV);Photodynamic therapy (PDT)