Risk Factors of Graft Failure in Post-Keratoplasty Ocular Hypertension.

Joo, Jongsoo; Lee, You Kyung; Joo, Choun Ki

doi:2012.53.3.385

J Korean Ophthalmol Soc > Volume 53(3); 2012 > Article

Original Article

Journal of the Korean Ophthalmological Society 2012;53(3):385-389.
DOI: https://doi.org/10.3341/jkos.2012.53.3.385 Published online March 15, 2012.

Risk Factors of Graft Failure in Post-Keratoplasty Ocular Hypertension.

Jongsoo Joo, You Kyung Lee, Choun Ki Joo

Department of Ophthalmology and Visual Science, The Catholic University of Korea School of Medicine, Seoul, Korea. ckjoo@catholic.ac.kr

전층각막이식술 후 발생한 고안압증 환자에서 이식 실패로 이행하는 위험인자

주종수⋅이유경⋅주천기

Department of Ophthalmology and Visual Science, The Catholic University of Korea School of Medicine, Seoul, Korea

Abstract

PURPOSE
To assess the risk factors proceeding to graft failure in post-keratoplasty ocular hypertension patients. METHODS: In 35 eyes diagnosed with post-keratoplasty ocular hypertension (graft failure: 13 eyes; graft survival: 22 eyes), relationships between graft status at the observation time and pre-keratoplasty diagnosis, lens status, history of graft failure, donor size, difference between donor and recipient graft size, donor corneal endothelial cell count, post-keratoplasty intraocular pressure (after 1 week and maintenance intraocular pressure after surgery), and number of antiglaucomatic agents were investigated. The relative risks of each factor to induce graft failure were also evaluated. RESULTS: Previous graft failure history, pre-existing pseudophakic bullous keratopathy and aphakia/pseudophakia showed statistically significant high probabilities of proceeding to graft failure (p < 0.05). In particular, the intraocular pressure 1 week after the graft was statistically higher (p < 0.05) in the graft failure group (24.31 +/- 8.82 mm Hg) than in the graft survival group (16.81 +/- 6.69 mm Hg). CONCLUSIONS: Strict management of intraocular pressure in the early phase of penetrating keratoplasty could contribute to reducing graft failure in post-keratoplasty ocular hypertension patients.

Key Words: Graft failure;Penetrating keratoplasty;Post-keratoplasty ocular hypertension