Three Cases of Rituximab Treatment for Orbital Inflammatory Disease.

Park, Byung Chun; Woo, Kyung In; Kim, Yoon Duck

doi:2012.53.5.721

J Korean Ophthalmol Soc > Volume 53(5); 2012 > Article

Case Report

Journal of the Korean Ophthalmological Society 2012;53(5):721-727.
DOI: https://doi.org/10.3341/jkos.2012.53.5.721 Published online May 15, 2012.

Three Cases of Rituximab Treatment for Orbital Inflammatory Disease.

Byung Chun Park, Kyung In Woo, Yoon Duck Kim

¹Department of Ophthalmology, Dongkang Medical Center, Ulsan, Korea.
²Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ydkimoph@skku.edu

염증성안와질환에서 Rituximab의 치료 3예

박병춘¹⋅우경인²⋅김윤덕²

Department of Ophthalmology, Dongkang Medical Center¹, Ulsan, Korea
Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine², Seoul, Korea

Abstract

PURPOSE
To report three cases of rituximab treatment in refractory orbital inflammatory disease. CASE SUMMARY: Rituximab treatment was performed in three patients (thyroid-associated ophthalmopathy, orbital myositis, and idiopathic sclerosing inflammation) unresponsive to corticosteroid and radiotherapy. One cycle consisted of intravenous infusion of 1000 mg of rituximab, twice at a two-week interval. The patient with thyroid-associated ophthalmopathy exhibited clinical improvement in visual acuity, color vision, visual evoked potential, and visual field after one cycle of rituximab treatment. The patient with orbital myositis improved showed diplopia with a decrease in the size of the extraocular muscle after two cycles of treatment. The patient with idiopathic sclerosing inflammation showed improvements in visual acuity and visual field defect after one cycle of therapy. There were no severe infections or hematologic adverse effects including neutropenia, or decreased immunoglobulin during the follow-up period. CONCLUSIONS: Treatment with rituximab appears to offer another therapeutic option in patients unresponsive to corticosteroid or radiotherapy.

Key Words: Inflammation;Orbit;Rituximab;Thyoid