Central Retinal Artery Obstruction in Protein S Deficiency.

Lee, Sung Bok; Yun, Yong Jun; Kim, Jung Yeul

doi:2008.49.12.2017

J Korean Ophthalmol Soc > Volume 49(12); 2008 > Article

Case Report

Journal of the Korean Ophthalmological Society 2008;49(12):2017-2020.
DOI: https://doi.org/10.3341/jkos.2008.49.12.2017 Published online December 15, 2008.

Central Retinal Artery Obstruction in Protein S Deficiency.

Sung Bok Lee, Yong Jun Yun, Jung Yeul Kim

¹Department of Ophthalmology, College of Medicine, Chungnam National Univercity, Deajeon, Korea. kimjy@cnu.ac.kr
²Chungnam National University, Research Institute for Medical Sciences, Deajeon, Korea.

단백질 S 결핍 환자에서 발생한 망막중심동맥폐쇄

이성복^1,2ㆍ윤용준¹ㆍ김정열^1,2

Department of Ophthalmology, College of Medicine, Chungnam National Univercity¹, Deajeon, Korea / Chungnam National University, Research Institute for Medical Sciences², Deajeon, Korea

Abstract

PURPOSE
To report a case of central retinal artery obstruction (CRAO) caused by protein S deficiency. CASE SUMMARY: A 36-year-old man presented with acutely reduced visual acuity in the right eye. The patient had no other diseases such as diabetes mellitus or hypertension. The visual acuity was 20/20 in the right eye and light perception in the left eye. Afferent pupillary defect was observed in theleft eye. Fundus examination showed diffuse retinal opacification and a cherry-red spot at the macula. Thus the patient was diagnosed with CRAO in the left eye. There were no abnormal findings on routine hematologic tests including blood coagulation test. Protein C activity, antithrombin III activation, anticardiolipin antibody were within normal limits but protein S activity was decreased. Thus, the patient was diagnosed with CRAO with protein S deficiency. CONCLUSIONS: Coagulation factors such as protein S need to be measuredin cases of CRAO in young patients without medical problems.

Key Words: Central retinal artery obstruction;Hypercoagulable state;Protein S