| Antiadhesive Effect of the Mixed Solution of Hyaluronate and Sodium Carboxymethylcellulose After Strabismus Surgery. |
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Sung Wook Kwon, Young Woo Seo, Yoonae A Cho |
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Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea. earth317@yahoo.co.kr |
| 가토에서 히알루론산나트륨과 카르복시메틸셀룰로오스나트륨 혼합액이 술 후 유착에 미치는 영향 |
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권성욱ㆍ서영우ㆍ조윤애 |
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Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea |
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| Abstract |
PURPOSE
To evaluate the effect of the mixed solution of hyaluronate and sodium carboxymethylcellulose (HACMC, Guardix-sol(R)) in reducing postoperative adhesion following strabismus surgery. METHODS: In 16 rabbits out of 20 rabbits, 3 mm recession of the superior rectus muscle was performed on both eyes and HACMC solution was applied only to one eye which was randomly chosen. The rabbits were divided into a surgery-HACMC group and a surgery-no HACMC group. As a control group, the remaining 4 rabbits had no procedures performed. After 3 weeks, both eyes of 8 rabbits with surgery and 2 rabbits of the control group were enucleated. After staining with hematoxylin-eosin and Masson's trichrome, a histologic examination was performed. In the remaining 10 rabbits, the severity of adhesion in muscle and adjacent tissues was observed by blunt dissection. A researcher blind to the experiments performed all the examinations. RESULTS: A significant reduction in the degree of adhesion (P=0.005) as well as decreased fibrosis (P=0.015) was observed in the surgery-HACMC group. CONCLUSIONS: The mixed solution of HACMC was effective in reducing postoperative adhesion after strabismus surgery in rabbits. |
| Key Words:
Adehesion;Sodium carboxymethylcellulose;Sodium hyaluronate;Strabismus surgery |
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