Analysis of Systemic Factors through Blood Examination in Normal-Tension Glaucoma Patients.

Lee, Na Young; Ahn, Myung Douk

doi:2010.51.2.241

J Korean Ophthalmol Soc > Volume 51(2); 2010 > Article

Original Article

Journal of the Korean Ophthalmological Society 2010;51(2):241-247.
DOI: https://doi.org/10.3341/jkos.2010.51.2.241 Published online February 15, 2010.

Analysis of Systemic Factors through Blood Examination in Normal-Tension Glaucoma Patients.

Na Young Lee, Myung Douk Ahn

¹Department of Ophthalmology, College of Medicine, The Catholic University of Korea and Visual Science, Seoul, Korea.
²Department of Ophthalmology, Incheon St. Mary's Hospital, Incheon, Korea.
³Department of Ophthalmology, Seoul St. Mary's Hospital, Seoul, Korea.

정상안압녹내장 환자에서 혈액검사를 통한 전신적 인자에 대한 분석

이나영^1,2ㆍ안명덕^1,3

Department of Ophthalmology, College of Medicine, The Catholic University of Korea and Visual Science¹, Seoul, Korea Department of Ophthalmology, Incheon St. Mary's Hospital², Incheon, Korea Department of Ophthalmology, Seoul St. Mary's Hospital³, Seoul, Korea

Abstract

PURPOSE
In this study, we evaluated systemic hemodynamic factors of normal tension glaucoma. METHODS: Forty patients with normal tension glaucoma and thirty healthy people were investigated with regard to hemoglobin, hematocrit, RBC count, WBC count, platelet count, fasting glucose, HbA1c, total cholesterol, triglycerides, LDL, HDL, and high-sensitivity C-reactive protein (hsCRP). Also, ET-1 and MCP-1 were measured using enzyme-linked immunosorbent assay kits. RESULTS: The results of the blood examinations showed no statistically significant differences in hemoglobin, hematocrit, RBC count, WBC count, platelet count, fasting glucose, HbA1c, total cholesterol, LDL, HDL, and hsCRP. Only triglycerides showed a statistically significant difference between the groups (P=0.03). The level of serum ET-1 was significantly higher in the normal tension glaucoma group (P=0.007). The results of MCP-1 showed no statistically significant difference. CONCLUSIONS: We conclude that normal tension glaucoma Is associated with an increased level of triglycerides and that the level of ET-1 could be a hemodynamic cause of normal tension glaucoma.

Key Words: Endothelin-1;Hemodynamic factors;High-sensitivity C-reactive protein;Macrophage chemoattractant protein-1;Normal tension glaucoma