J Korean Ophthalmol Soc > Volume 51(4); 2010 > Article
Journal of the Korean Ophthalmological Society 2010;51(4):542-551.
DOI: https://doi.org/10.3341/jkos.2010.51.4.542    Published online April 15, 2010.
Incidence (1991~1993) and Survival Rates (1991-2003) of Retinoblastoma in Korea.
Jeong Hun Kim, Young Suk Yu
1Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
2Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea. ysyu@snu.ac.kr
한국인 망막모세포종의 발생률(1991~1993)과 생존율(1991-2003) 보고
김정훈ㆍ유영석
Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea
Abstract
PURPOSE
To determine the incidence (1991~1993) and survival rates (1991~2003) of retinoblastoma in Korea. METHODS: Data of all Korean patients diagnosed with retinoblastoma from 1991-1993 were retrospectively collected by the hospital-based national registry based on notifications from physicians who are able to diagnose retinoblastoma. The incidence rate (1991~1993) was calculated per 100,000 childbirths (dividing the number of retinoblastoma patients by the total number of child-births). The survival rate (1991~2003) was calculated using the Kaplan-Meier method, and the differences were evaluated with the logrank and Wilcoxon tests and Cox's proportional hazards model.In addition, the clinical findings and prognostic factors associated with survival rate were analyzed. RESULTS: There were a total of 108 distinct patients diagnosed with retinoblastoma in the registry. The incidence of retinoblastoma in Koreawas 4.99 per 100,000 childbirths, and the survival rate for 13 years (1991-2003) was 77.8%. The survival rate was significantly lower in the population of bilateral retinoblastomapatients, as compared to unilateral retinoblastoma patients. Optic nerve invasion was found to be an independent variable for the reduction of survival rate, although its effects were not significant. CONCLUSIONS: In the present study, the incidence and survival rates of retinoblastoma in Koreawere presented for the first time. The incidence rate was similar to rates reported from other countries. On the other hand, the survival rate was lower than those in European and the United States. In particularly, the survival rate was significantly lower in patients with bilateral retinoblastoma.
Key Words: Incidence rate;Retinoblastoma;Survival rate


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