Two Cases of Lacrimal Drainage Obstruction Associated With S-1 Anticancer Treatment.

Park, Jong Seo; Ha, Sung Woo; Lew, Helen

doi:2010.51.6.890

J Korean Ophthalmol Soc > Volume 51(6); 2010 > Article

Case Report

Journal of the Korean Ophthalmological Society 2010;51(6):890-894.
DOI: https://doi.org/10.3341/jkos.2010.51.6.890 Published online June 15, 2010.

Two Cases of Lacrimal Drainage Obstruction Associated With S-1 Anticancer Treatment.

Jong Seo Park, Sung Woo Ha, Helen Lew

Department of Ophthalmology, Bundang CHA Medical Center, CHA University, Sungnam, Korea. eye@cha.ac.kr

S-1 전신 항암 요법 후 발생한 눈물길 폐쇄 2예

박종서ㆍ하성우ㆍ유혜린

Department of Ophthalmology, Bundang CHA Medical Center, CHA University, Sungnam, Korea

Abstract

PURPOSE
To report two cases of lacrimal drainage obstruction associated with the anticancer drug S-1 (tegafur, gimeracil, oteracil ; TS-1(R), Taiho Pharmaceutical, Japan). CASE SUMMARY: (Case 1) A 34-year-old male who had previously undergone a total gastrectomy for treatment of gastric cancer visited with epiphora in both eyes that had developed 6 months after S-1 treatment. On examination, a right canalicular obstruction and left punctal and nasolacrimal partial obstruction were noted. Endoscopic dacrycystorhinostomy with lacrimal trephinization was done in the right eye and punctoplasty with punctal membrane removal and silicone tube intubation were performed in the left eye and the epiphora were successfully treated. (Case 2) A 60-year-old male who was treated with S-1 for gastric cancer presented with tearing in both eyes that had developed 2 months after S-1 treatment. Ophthalmic examinations revealed a right nasolacrimal partial obstruction in the right eye and lacrimal sac obstruction in the left. Silicone intubations were performed on both sides and the epiphora were successfully treated. CONCLUSIONS: Lacrimal drainage obstructions may develop after S-1 treatment. Therefore, ophthalmologic evaluations should be performed in patients treated with S-1 to detect lacrimal drainage obstruction.

Key Words: Epiphora;Lacrimal drainage obstruction;S-1