Clinical Effects of Combination Therapy Using Heparin and Phospholipid in Severe Dry Eye Syndrome.

Joo, Kwang Sic; Chun, Yeoun Sook; Kim, Jae Chan

doi:2010.51.8.1047

J Korean Ophthalmol Soc > Volume 51(8); 2010 > Article

Original Article

Journal of the Korean Ophthalmological Society 2010;51(8):1047-1053.
DOI: https://doi.org/10.3341/jkos.2010.51.8.1047 Published online August 15, 2010.

Clinical Effects of Combination Therapy Using Heparin and Phospholipid in Severe Dry Eye Syndrome.

Kwang Sic Joo, Yeoun Sook Chun, Jae Chan Kim

Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul, Korea. JCK50ey@kornet.net

중증 건성안에서 헤파린과 인지질을 사용한 복합치료의 임상적 효과

주광식ㆍ전연숙ㆍ김재찬

Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul, Korea

Abstract

PURPOSE
To evaluate the therapeutic effects of topical heparin (Hylo-Parin(R), Ursapharm Saarbr cken, Germany) and spray type phospholipids (Tears Again(R), Optima Pharmazeutische GmbH. Freising, Germany) in severe dry eye syndrome resistant to conventional therapy. METHODS: Twenty eyes of ten patients with refractory severe dry eye were treated with Hylo-Parin(R) (two times a day) and Tears Again(R) (three times a day) for three months. Before and one and three months after treatment, a symptom questionnaire was administered to the patients. The ocular surface disease index (OSDI), tear film break-up time, Schirmer test, conjunctival fluorescein staining examinations and filamentary keratitis were evaluated. RESULTS: After using Tears Again(R) and Hylo-Parin(R), the OSDI score improved from 64.13 +/- 15.12 to 43.80 +/- 15.87 (p<0.01). Tear film break-up time significantly increased from 1.0 +/- 0.65 to 2.3 +/- 0.73 seconds (p<0.01) and conjunctival staining score (Oxford scale) significantly decreased from 3.85 +/- 0.75 to 3.25 +/- 0.97 (p<0.01). Filamentary keratitis in the slit-lamp examination showed significant improvement (p<0.01). CONCLUSIONS: Tears Again(R) and Hylo-Parin(R) are considered as new treatment modalities for severe dry eye syndrome and filamentary keratitis in patients with chronic ocular surface disease resistant to conventional therapy. These treatments require additional research.

Key Words: Dry eye;Filamentary keratitis;Heparin;Liposome;Phospholipid