Noninfectious Severe Early Chamber Reaction after Penetrating Keratoplasty.

Lim, Su Jin; Kim, Su Young; Kim, Man Soo

Original Article

Journal of the Korean Ophthalmological Society 2007;48(3):343-347.
Published online March 31, 2007.

Noninfectious Severe Early Chamber Reaction after Penetrating Keratoplasty.

Department of Ophthalmology, Gangnam St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Seoul Korea. mskim@catholic.ac.kr

각막이식직후 발생한 비감염성 전방 염증

임수진,김수영,김만수

Department of Ophthalmology, Gangnam St. Mary`s Hospital, The Catholic University of Korea, College of Medicine, Seoul Korea

Correspondence: Su Jin Lim, M.D.

Abstract

PURPOSE
To report 8 cases of Noninfectious early anterior chamber reaction after penetrating keratoplasty (PKP), and to review relevant literature. METHODS: Retrospectively, we reviewed medical records of 8 patients who had undergo PKP from March 2001 to May 2004, associated with early severe chamber reaction. RESULTS: Preoperative diagnosis are corneal opacity (4 cases), keratoconus (2 cases), corneal ectasia after LASIK (1 case) and graft failure (1 case). Although they didn't show severe chamber reaction at first day after surgery, the anterior chamber reaction with cornea edema and decreased visual acuity had increased with time. We didn't give the additional treatment except increasing the number of instillation of topical steroid. The inflammation was improved within a week and the complete resolution was achieved during the follow-up in all cases. In all cases posterior synechia and anterior subcapsular opacity were found. CONCLUSIONS: It seems reasonable to conclude that a single common etiologic factor could not responsible for this syndrome. Non-infectious inflammation developing upon PKP may be caused by a multifactorial process like increased IOP, toxic anterior segment syndrome form surgical trauma or hypersensitivity reaction et al and viscoelastics effect.

Key Words: Chamber reaction;Inflammation;Penetrating keratoplasty