Journal of the Korean Ophthalmological Society 2007;48(3):348-355.
Published online March 31, 2007.
Changes of Tear Film and Ocular Surface with Time after Penetrating Keratoplasty.
In Seong Kang, In Chun You, Kyung Chul Yoon
Department of Ophthalmology, Chonnam National University Medical School & Hospital, Gwang-ju, Korea. kcyoon@chonnam.ac.kr
전층각막이식술 후 시간의 경과에 따른 눈물막과 안구표면의 변화
강인성,유인천,윤경철
Department of Ophthalmology, Chonnam National University Medical School & Hospital, Gwang-ju, Korea
Correspondence:  In Seong Kang, M.D.
Abstract
PURPOSE
To evaluate the parameters of tear function and ocular surface changes with time course after penetrating keratoplasty (PKP). METHODS: Corneal sensitivity test (CST), tear film break-up time (BUT), basal tear secretion test (BST), tear clearance test (Tcr), fluorescein staining and conjunctival impression cytology were evaluated in 21 eyes of 21 patients who underwent PKP at 1, 3 and 6 months postoperatively. RESULTS: CST (p=0.02), BST (p=0.04), fluorescein scoring (p=0.03), and goblet cell density (p=0.03) showed improving tendency during 6 month after surgery, but BUT (p=0.11), Tcr (p=0.65) and squamous metaplasia (p=0.20) did not change significantly. One month after surgery, CST (p<0.01), BUT (p=0.01), BST (p<0.01), and goblet cell density (p=0.01) were lower, while fluorescein staining score (p<0.01) and the grade of squamous metaplasia (p=0.03) were higher in PKP group. Six months after surgery, CST (p<0.01) and goblet cell density (p=0.04) were lower, and fluorescein staining score (p<0.01) was higher in PKP group. CONCLUSIONS: Tear film and ocular surface are compromised after PKP and improved gradually during postoperative 6 months. However, these parameters were not recovered completely to the normal level.
Key Words: Ocular surface;Pentrating keratoplasty;Tear film


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