| Photodynamic Therapy for Choroidal Neovascularization Secondary to Age-Related Macular Degeneration. |
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Hyeong Gon Yu, Se Woong Kang, Woo Ho Nam, Hyoung Jun Koh, Hyung Woo Kwak, Oh Woong Kwon, Si Yeol Kim, In Taek Kim, Ha Kyoung Kim, Hyun Woong Kim, Young Jung Roh, Jun Woong Moon, Kyu Hyung Park, Suk Ho Byeon, Su Jeong Song, Jae Kyoun Ahn, Boo Sup Oum, Jae Ryung Oh, Seung Young Yu, Ill Han Yoon, Sung Chul Lee, Won Ki Lee, Jae Heung Lee, Jeong Hee Lee, Ji Eun Lee, Tae Gon Lee, Gwang Ju Choi, Don Il Ham, Kuhl Huh, Hum Chung |
1Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. chungh@snu.ac.kr
2Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
3Department of Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University, College of Medicine, Seoul, Korea.
4Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
5Department of Ophthalmology, KyungHee University College of Medicine, Seoul, Korea.
6Department of Ophthalmology, Kyungpook National University, College of Medicine, Daegu, Korea.
7Department of Ophthalmology, College of Medicine, Inje University, Pusan, Korea.
8Department of Ophthalmology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
9Department of Ophthalmology, Konkuk University College of Medicine, Seoul, Korea.
10Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
11Department of Ophthalmology, Chonnam National University Medical School & Hospital, Gwangju, Korea.
12Department of Ophthalmology, College of Medicine, Pusan National University, Pusan, Korea.
13Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
14Department of Ophthalmology, Konyang University, Kim's Eye Hospital, Seoul, Korea.
15Department of Ophthalmology, Ewha Womans University College of Medicine, Seoul, Korea.
16Department of Ophthalmology, The Chosun University Medical College, Gwangju, Korea. |
| 나이관련황반변성에서 발생한 맥락막신생혈관 환자에서 반복 시행한 광역학치료의 효과 |
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유형곤1,강세웅2,남우호3,고형준4,곽형우5,권오웅4,김시열6,김인택6,김하경3,김현웅7,노영정8,문준웅9,박규형1,변석호4,송수정10,안재균11,엄부섭12,오재령13,유승영5,윤일한7,이성철4,이원기8,이재흥14,이정희15,이지은12,이태곤14,최광주16,함돈일2,허걸13,정흠1 |
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Department of Ophthalmology, Seoul National University College of Medicine1, Seoul, Korea, Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine2, Seoul, Korea, Department of Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University, College of Medicine3, Seoul, Korea, Department of Ophthalmology, Yonsei University College of Medicine4, Seoul, Korea, Department of Ophthalmology, KyungHee University College of Medicine5, Seoul, Korea, Department of Ophthalmology, Kyungpook National University, College of Medicine6, Daegu, Korea, Department of Ophthalmology, College of Medicine, Inje University7, Pusan, Korea, Department of Ophthalmology, College of Medicine, The Catholic University of Korea8, Seoul, Korea, Department of Ophthalmology, Konkuk University College of Medicine9, Seoul, Korea, Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine10, Seoul, Korea, Department of Ophthalmology, Chonnam National University Medical School & Hospital11, Gwangju, Korea, Department of Ophthalmology, College of Medicine, Pusan National University12, Pusan, Korea, Department of Ophthalmology, Korea University College of Medicine13, Seoul, Korea, Department of Ophthalmology, Konyang University, Kim??s Eye Hospital14, Seoul, Korea, Department of Ophthalmology, Ewha Womans University College of Medicine15, Seoul, Korea, Department of Ophthalmology, The Chosun University Medical College16, Gwangju, Korea |
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Correspondence:
Hyeong Gon Yu, M.D.1 |
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| Abstract |
PURPOSE
To investigate the effects of repeated photodynamic therapy (PDT) for subfoveal choroidal neovascularization secondary to age-related macular degeneration (AMD) in Korean patients. METHODS: Clinical data of patients who were treated with repeated (3 times or more) PDT for subfoveal choroidal neovascularization secondary to AMD and followed up for more than 6 months were collected from 17 hospitals around the country. Visual outcomes at 12 and 24 months, follow-up were compared between subtypes of choroidal neovascularization. The factors related to final visual prognosis and PDT-related adverse effects were evaluated. RESULTS: 244 patients (244 eyes) were recruited (male: 60%, age: 67.7+/-9.1 years). The portion of patients with predominantly classic, minimally classic, and occult without classic choroidal neovascularization was 57%, 13%, and 24%, respectively and that of patients with visual improvements or less than moderate visual loss at 24 months follow-up were 28%, 38%, 30% and 47%, 56%, and 65%, respectively. Baseline visual acuity and age were significantly related to the final visual prognosis (p<0.05). PDT-related adverse events developed in 15 (6.1%) patients, but most were mild and transient. CONCLUSIONS: Repeated PDT for subfoveal choroidal neovascularization secondary to AMD has effects comparable to those of previous prospective, controlled trials without any significant safety concerns in Korea. |
| Key Words:
Age-related macular degeneration (AMD);Choroidal neovascularization (CNV);Photodynamic therapy (PDT) |
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