J Korean Ophthalmol Soc > Volume 48(8); 2007 > Article
Journal of the Korean Ophthalmological Society 2007;48(8):1036-1040.
DOI: https://doi.org/10.3341/jkos.2007.48.8.1036-1040    Published online August 31, 2007.
The Efficacy of Amniotic Membrane Graft in the Treatment of Symptomatic Bullous Keratopathy.
Jung Hyun Park, Jin Wook Jeoung, Won Ryang Wee, Jin Hak Lee, Mee Kum Kim, Jae Lim Lee
1Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. kmk9@snu.ac.kr
2Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.
3Valued Eye Clinic, Seoul, Korea.
수포각막병증에서 양막 이식술의 효용성
Department of Ophthalmology, Seoul National University College of Medicine1, Seoul, Korea Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital2, Seoul, Korea Valued Eye Clinic3, Seoul, Korea
Correspondence:  Mee Kum Kim, M.D.
To evaluate the efficacy of amniotic membrane (AM) transplantation in symptomatic bullous keratopathy using cryo-preserved or lyophilized AM. METHODS: Eight bullous keratopathic patients, who experienced intractable pain despite medication and the application of a therapeutic lens, underwent permanent AM transplantation with 5 cryo-preserved and 3 lyophilized AMs following removal of epithelium using a trephine. The time to re-epithelization and the subsidence of pain were evaluated retrospectively. RESULTS: Mean follow-up was 252+/-171.0 days. Pain relief and re-epithelization were obtained in all eight patients. The times to complete relief of pain was 32.2+/-22.7 days in patients with cryo-preserved AM transplantations (n=5) and 22.0+/-18.0 days in those with lyophilized AM transplantations (n=3) (p=0.549, Mann-Whitney U test). Respective times to re-epithelization were 25.4+/-20.7 days and 23.0+/-25.2 days (p=0.297). There were no significant differences in the diameter of transplanted AMs between the two groups (7.6+/-0.2 vs. 7.3+/-0.3 mm, p=0.172). CONCLUSIONS: Permanent AM transplantation effectively reduced the intractable pain caused by epithelial bulla. Whether the AM was cryo-preserved or lyophilized did not affect the efficacy of the treatment.
Key Words: Amniotic membrane transplantation;Bullous keratophathy;Epithelization;Preservation

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