Clinical Results of Corneal Triple Procedure and Risk Factors for Graft Failure.

Jeong, Tae Sun; Moon, Hyung Jin; You, In Chon; Yoon, Kyung Chul

doi:2007.48.12.1607

J Korean Ophthalmol Soc > Volume 48(12); 2007 > Article

Original Article

Journal of the Korean Ophthalmological Society 2007;48(12):1607-1613.
DOI: https://doi.org/10.3341/jkos.2007.48.12.1607 Published online December 31, 2007.

Clinical Results of Corneal Triple Procedure and Risk Factors for Graft Failure.

Tae Sun Jeong, Hyung Jin Moon, In Chon You, Kyung Chul Yoon

Department of Ophthalmology, Chonnam National University Medical School, Gwangju, Korea. kcyoon@chonnam.ac.kr

각막이식 삼중수술의 임상적 결과와 이식실패의 위험인자

정태선,문형진,유인천,윤경철

Department of Ophthalmology, Chonnam National University Medical School, Gwangju, Korea

Correspondence: Kyung Chul Yoon, M.D.

Abstract

PURPOSE
To evaluate the clinical results of corneal triple procedure, as well as the causes and the risk factors for graft failure. METHODS: Indications, survival period of graft, causes of graft failure, and risk factors for failure in 29 patients (29 eyes) who had undergone penetrating keratoplasty combined with cataract surgery and intraocular lens (IOL) implantation were retrospectively analyzed. RESULTS: The most common primary indication of corneal triple procedure was bacterial keratitis (24%), followed by corneal trauma, herpes simplex keratitis, and graft failure. The average survival period of corneal graft in corneal triple procedure was 29.2+/-23.2 months. The most common cause of graft failure was allograft rejection (56.3%). The risk factors of graft failure by an univariate analysis were preoperative unfavorable diagnosis (bullous keratopathy, corneal ulcer, and trauma), corneal neovasculization, intraoperative additional procedure (anterior vitrectomy, synechiolysis, and anterior chamber irrigation), immune rejection, and postoperative glaucoma, but were unrelated to methods of cataract surgery, graft size, or IOL position. In a multivariate analysis, graft rejection and corneal neovascularization were identified as risk factors for graft failure in patients undergoing triple procedure. CONCLUSIONS: Corneal graft in corneal triple procedure had various success rates according to the many factors. Risk factors for graft failure included graft rejection and corneal neovascularization.

Key Words: Corneal triple procedure;Graft failure;Risk factor