| Ocular Concentration after Subtenon and Intravitreal Injection of Triamcinolone Acetonide in Rabbits. |
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Yong Wook Park, Jung Hoon Lim, Jae Pil Shin, Si eol Kim |
1Department of Ophthalmology, Kyungpook National University College of Medicine, Daegu, Korea. kimsy@knu.ac.kr
2Department of Ophthalmology, Cheil Eye Hospital, Daegu, Korea. |
| 토끼에서 유리체강내 및 테논낭하 트리암시놀론 주사 후 시간에 따른 안내 농도변화 |
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박용욱1ㆍ임정훈2ㆍ신재필1ㆍ김시열1 |
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"Department of Ophthalmology, Kyungpook National University College of Medicine1, Daegu, Korea Department of Ophthalmology, Cheil Eye Hospital2, Daegu, Korea" |
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Correspondence:
Yong Wook Park, M.D.1 |
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| Abstract |
PURPOSE
To improve our understanding of the pharmacokinetics of triamcinolone acetonide (TA) and TA concentration in ocular tissue, TA concentration was measured in ocular tissue after intravitreal and subtenon injection. METHODS: Fifteen rabbit eyes underwent subtenon TA injection (40 mg/1 ml), and another 15 rabbit eyes underwent intravitreal TA (4 mg/0.1 ml) injection. All eyes were enucleated at 1, 2, 4, 8, and 12 weeks after subtenon and intravitreal injection, and TA concentration in the aqueous and vitreous humor and the retina-choroid were measured by high performance liquid chromatography (HPLC). RESULTS: In cases of subtenon's TA injection, TA concentrations were 0 ng/ml, 136.7 ng/ml, 178.7 ng/ml, 0 ng/ml, and 0 ng/ml in the aqueous humor; 99.1 ng/ml, 125.7 ng/ml, 726.8 ng/ml, 0 ng/ml, and 0 ng/ml in the vitreous humor; 72.7 ng/ml, 304.6 ng/ml, 459.0 ng/ml, 0 ng/ml, and 0 ng/ml in the retina-choroid after 1, 2, 4, 8, and 12 weeks, respectively. In cases of intravitreal TA injection, the measured values were 0 ng/ml, 0 ng/ml, 0 ng/ml, 654.1 ng/ml, and 0 ng/ml in the aqueous humor; 28152.2 ng/ml, 13646.4 ng/ml, 11388.8 ng/ml, 10297.2 ng/ml, and 183.0 ng/ml in the vitreous humor; and 0 ng/ml, 27.9 ng/ml, 108.3 ng/ml, 0 ng/ml, and 0 ng/ml in the retina-choroid at each time point. CONCLUSIONS: Intravitreal TA injection may be more effective for drug delivery than subtenon TA injection, but subtenon TA injection seems to be an effective and safe technique. |
| Key Words:
Intravitreal injection;Subtenon injection;Triamcinolone acetonide |
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