Intravitreal Tissue Plasminogen Activator with C3F8 Injection in Branch Retinal Vein Occlusion.

Lim, Ji Won; Choi, Jung Hoon; Park, In Won

doi:2008.49.3.450

J Korean Ophthalmol Soc > Volume 49(3); 2008 > Article

Original Article

Journal of the Korean Ophthalmological Society 2008;49(3):450-455.
DOI: https://doi.org/10.3341/jkos.2008.49.3.450 Published online March 31, 2008.

Intravitreal Tissue Plasminogen Activator with C3F8 Injection in Branch Retinal Vein Occlusion.

Ji Won Lim, Jung Hoon Choi, In Won Park

Department of Ophthalmology, Hallym University Sacred Heart Hospital, Gyeonggi, Korea. piw@korea.com

망막분지정맥폐쇄에서 시행한 조직플라스미노겐활성체 및 C3F8의 유리체강내주입술

임지원·최정훈·박인원

Department of Ophthalmology, Hallym University Sacred Heart Hospital, Gyeonggi, Korea

Correspondence: Ji Won Lim, M.D.

Abstract

PURPOSE
To evaluate the efficacy of intravitreal tissue plasminogen activator (tPA) with C3F8 injection for branch retinal vein occlusion (BRVO) involving fovea. METHODS: Seven patients (7 eyes) presenting with subfoveal hemorrhage caused by BRVO were treated with an intravitreal tPA and C3F8 injection. We assessed the visual acuity (VA) and foveal thickness measured with optical coherence tomography. RESULTS: The mean duration of symptoms before surgery was 5.42+/-1.90 weeks. The mean logMAR VA improved from 1.14+/-0.19 at baseline to 0.87+/-0.34 at one week and 0.30+/-0.32 at six months. The mean foveal thickness decreased from 564.421+/-186.88 micrometer at baseline to 483.14+/-275.06 micrometer at one week and 353.28+/-152.99 micrometer at six months. There was no adverse effect related to the treatment. CONCLUSIONS: Intravitreal tPA with C3F8 injection may be an effective treatment for resolving macular edema with subfoveal hemorrhage and improving the VA in recently developed BRVO.

Key Words: Branch retinal vein occlusion;Intravitreal injection;Tissue plasminogen activator