A Case of Valganciclovir Treatment for Cytomegalovirus Retinitis.

Kim, Na Rae; Moon, Yeon Sung; Chin, Hee Seung; Yoon, Jun Ho

doi:2008.49.3.531

J Korean Ophthalmol Soc > Volume 49(3); 2008 > Article

Case Report

Journal of the Korean Ophthalmological Society 2008;49(3):531-538.
DOI: https://doi.org/10.3341/jkos.2008.49.3.531 Published online March 31, 2008.

A Case of Valganciclovir Treatment for Cytomegalovirus Retinitis.

Na Rae Kim, Yeon Sung Moon, Hee Seung Chin, Jun Ho Yoon

¹Department of Ophthalmology, Inha University School of Medicine, Incheon, Koera.
²Ophthalmologic Oncology Clinic, National Cancer Center, Gyeonggi, Korea. dreye@freechal.com

Valganciclovir를 이용한 거대세포바이러스망막염의 치료

김나래¹ㆍ문연성¹ㆍ진희승¹ㆍ윤준호²

Department of Ophthalmology, Inha University School of Medicine1, Incheon, KoeraOphthalmologic Oncology Clinic, National Cancer Center2, Gyeonggi, Korea

Correspondence: Na Rae Kim, M.D.1

Abstract

PURPOSE
To report a case of a patient with cytomegalovirus (CMV) retinitis who was treated with oral valganciclovir. CASE SUMMARY: A 34-year-old man who had undergone anti-cancer chemotherapy for Non-Hodgkin lymphoma was referred to the ophthalmologic oncology clinic because of decreased vision in both eyes. Fundus examination showed white, opaque, and granular retinal lesions in both eyes, and a serologic test showed a positive response to CMV antibody IgG and a negative response to CMV antibody IgM. The patient received induction therapy with intravenous ganciclovir and maintenance therapy with oral valganciclovir 900 mg once daily. CMV retinitis reactivated 4 weeks after maintenance therapy was discontinued. At that point, the patient received induction therapy with oral valganciclovir 900 mg twice daily for 3 weeks and maintenance therapy with 900 mg once daily for 5 weeks. The retinal lesion disappeared and did not recur after oral administration of valganciclovir. The patient discontinued valganciclovir after 5 weeks of maintenance therapy, and CMV retinitis did not reactivate during 6 months of follow-up. CONCLUSIONS: Oral valganciclovir was clinically effective in the treatment of CMV retinitis in a patient who was treated with anti-cancer chemotherapy for non-Hodgkin lymphoma.

Key Words: Cytomegalovirus Retinitis;Ganciclovir;Valganciclovir