J Korean Ophthalmol Soc > Volume 49(4); 2008 > Article
Journal of the Korean Ophthalmological Society 2008;49(4):589-594.
DOI: https://doi.org/10.3341/jkos.2008.49.4.589    Published online April 15, 2008.
Intraocular Pressure Elevation After Intravitreal Triamcinolone Acetonide of Different Volumes: Comparing 0.1 ml vs 0.05 ml.
Sung Yong Park, Kyung Seek Choi
Department of Ophthalmology, Soonchunhyang University, College of Medicine, Seoul, Korea. ckseek@naver.com
유리체강내 트리암시놀론 주사시 트리암시놀론 용적에 따른 안압상승 양상
Department of Ophthalmology, Soonchunhyang University, College of Medicine, Seoul, Korea
To assess whether a 4 mg/0.05 ml intravitreal triamcinolone acetonide injection can reduce the IOP elevation compared to conventional 4 mg/0.1 ml injection. METHODS: A retrospective case study was performed in 48 patients (48 eyes) who received intravitreal triamcinolone acetonide injection and who had a minimum follow-up time of six months. Patients were randomly assigned to receive 4 mg/0.1 ml or 4 mg/0.05 ml (24 patients in each group). RESULTS: Before injection, mean IOP was 13.8+/-2.2 mmHg and 13.9+/-2.4 mmHg in the 0.1 ml and 0.05 ml group. The difference in IOP elevation between the two groups was statistically significant immediately after injection (P=0.000), one hour after injection (P=0.001), and one day after injection (P=0.000). After injection, the central macular thickness decreased significantly the of two groups. The difference of the central macular thickness decrease between both groups was not statistically significant. CONCLUSIONS: An intravitreal triamcinolone acetonide 4 mg/0.05 ml injection will more quickly reduce the IOP elevation in the early phase compared to 4 mg/0.1 ml injection, while providing a similar effect on the change of central macular thickness.
Key Words: Central macular thickness;Intraocular pressure;Intravitreal triamcinolone acetonide injection

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