J Korean Ophthalmol Soc > Volume 49(4); 2008 > Article
Journal of the Korean Ophthalmological Society 2008;49(4):634-640.
DOI: https://doi.org/10.3341/jkos.2008.49.4.634    Published online April 15, 2008.
The Effect of Intracameral Triamcinolone Acetonide Injection on the Cornea in Rabbits.
Joo Youn Park, Hoon Dong Kim, Kyung Seek Choi
Department of Ophthalmology, Soonchunhyang University College of Medicine, Seoul, Korea. ckseek@naver.com
가토안에서 전방내 트리암시놀론 주입술이 각막에 미치는 영향
박주연ㆍ김훈동ㆍ최경식
Department of Ophthalmology, Soonchunhyang University College of Medicine, Seoul, Korea
Abstract
PURPOSE
To evaluate the safety and effects of intracameral triamcinolone acetonide injection in rabbit corneas. METHODS: Triamcinolone acetonide in the amounts of 0.5, 1, and 2 mg was injected into the anterior chamber of rabbit eyes, and intraocular pressure, corneal thickness, and endothelial cell counts were evaluated on days 1, 3, 7, 14, and 28. Twenty-eight days after triamcinolone acetonide injection, the eyes were enucleated and examined after TUNEL staining. RESULTS: No statistically significant differences were found among control, 0.5, and 1 mg triamcinolone-injected eyes in central corneal thickness, endothelial cell density, pleomorphism, and polymegathism. There was no difference between 2 mg triamcinolone-injected eyes and control eyes for corneal thickness and cell density, but there were statistically significant differences between these two groups for pleomorphism (p<0.05) and polymegathism (p<0.05). CONCLUSIONS: The results of this study suggested that intracameral injections of 0.5~1 mg of triamcinolone acetonide are beneficial and cause no toxic effects on corneas.
Key Words: Cornea;Intracameral triamcinolone acetonide injection


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