J Korean Ophthalmol Soc > Volume 49(5); 2008 > Article
Journal of the Korean Ophthalmological Society 2008;49(5):743-752.
DOI: https://doi.org/10.3341/jkos.2008.49.5.743    Published online May 15, 2008.
Prophylactic Effect of Brimonidine 0.15% on IOP Elevation After Intravitreal Triamcinolone Acetonide Injection.
Myung Won Lee, Sung Eun Kyung, Moo Hwan Chang
Department of Ophthalmology, Dankook University College of Medicine, Cheonan, Korea. changmh@dankook.ac.kr
유리체강내 트리암시놀론 주입술 후 예방적 안압하강제의 효과
이명원ㆍ경성은ㆍ장무환
Department of Ophthalmology, Dankook University College of Medicine, Cheonan, Korea
Abstract
PURPOSE
The purpose of this study was to investigate the prophylactic effect of brimonidine 0.15% on intraocular pressure (IOP) elevation and the risk factors for its elevation after intravitreal triamcinolone acetonide injection (IVTA). METHODS: A prospective, randomized clinical trial was conducted on 67 eyes of 64 patients undergoing IVTA. Eyes were randomly divided into two groups, those which had used brimonidine 0.15% (40 eyes) and those which had not used it (27 eyes). IOP was measured preoperatively, at one week, and monthly until six months post-injection in each group. RESULTS: The mean post.injection IOP at one week was 11.93+/-3.36 mmHg for the group that had used brimonidine and 13.58+/-3.25 mmHg for the group that had not used it. The difference between the two groups was statistically significant at one week (p=0.049), but others were not statistically significant. An elevation in the IOP of more than 22 mmHg was seen in 8 eyes (20%) in the group using brimonidine and in 7 eyes (25.9%) in the group not using brimonidine. There was no difference in the incidence of IOP elevation between the two groups. CONCLUSIONS: Prophylactic use of brimonidine 0.15% will prevent sudden IOP elevation and will, therefore, prevent damage to the retina and optic nerve. However, in the long term, there is no prophylactic effect of brimonidine 0.15% on IOP elevation because there was no difference in the incidence of IOP elevation of more than 22 mmHg between the two groups.
Key Words: Brimonidine;Intravitreal injection;Intraocular pressure;Triamcinolone acetonide


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