J Korean Ophthalmol Soc > Volume 49(9); 2008 > Article
Journal of the Korean Ophthalmological Society 2008;49(9):1475-1482.
DOI: https://doi.org/10.3341/jkos.2008.49.9.1475    Published online September 15, 2008.
Analysis of Intraocular Chemokine and Chemokine Receptor in Patients with HLA-B27-associated Anterior Uveitis.
Tae Wan Kim, Hum Chung, Hyeong Gon Yu
1Department of Ophthalmology, Seoul Metropolitan Boramae Hospital, Seoul, Korea.
2Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. hgonyu@snu.ac.kr
3Medical Research Center, Seoul National University, Seoul, Korea.
인체 백혈구 항원-B27 연관 앞포도막염 환자의 방수 내 키모카인 및 키모카인 수용체 분석
김태완1,2,3ㆍ정흠2ㆍ유형곤2,3
Department of Ophthalmology, Seoul Metropolitan Boramae Hospital1, Seoul, Korea / Department of Ophthalmology, Seoul National University College of Medicine2, Seoul, Korea / Medical Research Center, Seoul National University3, Seoul, Korea
Abstract
PURPOSE
To evaluate the expression of chemokine and chemokine receptors in the aqueous humor (AH) of patients with recurrent anterior uveitis (AU) in terms of HLA-B-27-association. METHODS: Patients with endogenous uveitis were recruited from the uveitis clinic at Seoul National University Hospital. AH and peripheral blood (PB) were obtained from each patient. The expression of chemokine receptors in T-cells from AH and PB was measured using flow cytometric analysis. Interleukin (IL)-8, interferon-gammainducible protein (IP)-10, and regulated-on-expression, normal T-cell expressed and secreted (RANTES) levels of PB and AH were measured. The expression of chemokine receptor and chemokine levels in PB and AH were compared between HLA-B27-associated AU and idiopathic AU patients. RESULTS: Seventeen patients with HLA-B27-associated AU, 14 patients with idiopathic AU and 5 healthy controls were included in this study. IL-8 and IP-10 levels of AH were shown to be increased more than in PB, and intraocular concentrations of IL-8 and IP-10 were higher in patients with HLA-B27-associated AU than in idiopathic AU patients. RANTES levels in AH were significantly lower than in PB for all groups. In all groups, the expression of chemokine receptor in AH increased more than in PB. CONCLUSIONS: The results from this study show chemokine may play an important role in inflammation in patients with AU. This implies that the chemokine environment may be different in terms of HLA-B-27-association.
Key Words: Chemokine;Chemokine receptor;HLA-B27-associated anterior uveitis


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