I-TAC Concentration in Tears of Dry Eye Patients and Its Correlation with Tear Surface Parameters.

Kim, Hwang Gyun; You, In Cheon; Yoon, Kyung Chul

doi:2008.49.10.1565

J Korean Ophthalmol Soc > Volume 49(10); 2008 > Article

Original Article

Journal of the Korean Ophthalmological Society 2008;49(10):1565-1571.
DOI: https://doi.org/10.3341/jkos.2008.49.10.1565 Published online October 15, 2008.

I-TAC Concentration in Tears of Dry Eye Patients and Its Correlation with Tear Surface Parameters.

Hwang Gyun Kim, In Cheon You, Kyung Chul Yoon

¹Department of Ophthalmology, Chonnam National University and Hospital, Gwangju, Korea. kcyoon@chonnam.ac.kr
²Department of Ophthalmology, Chonbuk National University, College of Medicine, Chonbuk, Korea.

건성안 환자의 눈물에서 인터페론유도 T 세포 화학주성인자의 농도와 눈물표면인자와의 상관관계

김황균¹ㆍ유인천^²ㆍ윤경철¹

Department of Ophthalmology, Chonnam National University and Hospital1, Gwangju, Korea / Department of Ophthalmology, Chonbuk National University, College of Medicine2, Chonbuk, Korea

Abstract

PURPOSE
This study was performed to evaluate the level of I-TAC in tears of patients with dry eye syndrome and its correlation with the tear surface parameters. METHODS: I-TAC levels were measured by enzyme-linked immunosorbent assay (ELISA) in tear samples collected from 33 dry eye patients (16 patients with Sjogren syndrome and 17 patients with non-Sjogren syndrome) and 15 control subjects. The correlations between I-TAC levels and tear surface parameters including tear film break-up time (BUT), basal tear secretion, tear clearance rate (TCR), corneal sensation, keratoepitheliopathy and conjunctival goblet cell density were analyzed. RESULTS: The mean levels of I-TAC were 717+/-377 pg/ml in patients with dry eye and 444+/-119 pg/ml in control subjects (P=0.003). The mean levels in Sjogren syndrome patients (1261+/-324 pg/ml) were significantly higher than those of non-Sjogren syndrome patients (614+/-131 pg/ml, P=0.003). I-TAC levels correlated significantly with basal tear secretion (P=0.006), TCR (P=0.007), keratoepitheliopathy (P=0.022) and goblet cell density (P<0.001), but did not correlate with BUT (P=0.110) and corneal sensation (P=0.090). CONCLUSIONS: The level of I-TAC is elevated in tears of patients with dry eye syndrome including Sjogren syndrome. The level correlates with disease severity and tear surface parameters.

Key Words: Chemokine;Dry eye syndrome;I-TAC