| Clinical Evaluation of Patients with Nonproliferative Diabetic Retinopathy Following Medication of Anthocyanoside: Multicenter Study. |
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Eung Suk Kim, Seung Young Yu, Soon Jae Kwon, Oh Woong Kwon, Si Yeol Kim, Tae Wan Kim, Jae Kyoun Ahn, Boo Sup Oum, Young Ju Lew, Ji Eun Lee, Hum Chung, Hyung Woo Kwak |
1Department of Ophthalmology, KyungHee University College of Medicine, Seoul, Korea. hwkwak@khu.ac.kr
2Department of Ophthalmology, Kyungpook National University, College of Medicine, Daegu, Korea.
3Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
4Seoul National University Boramae Hospital, Seoul, Korea.
5Department of Ophthalmology, Chonnam National University Medical School & Hospital, Gwangju, Korea.
6Department of Ophthalmology, College of Medicine, Pusan National University, Pusan, Korea.
7Department of Ophthalmology, Konyang University, Kim's Eye Hospital, Seoul, Korea.
8Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. |
| 황반부종을 동반한 비증식당뇨망막병증 환자에서 Anthocyanoside 복용 후 임상변화 |
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김응석1ㆍ유승영1ㆍ권순재2ㆍ권오웅3ㆍ김시열2ㆍ김태완4ㆍ안재균5ㆍ엄부섭6ㆍ유영주7ㆍ이지은6ㆍ정흠8ㆍ곽형우1 |
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Department of Ophthalmology, KyungHee University College of Medicine1, Seoul, Korea / Department of Ophthalmology, Kyungpook National University, College of Medicine2, Daegu, Korea / Department of Ophthalmology, Yonsei University College of Medicine3, Seoul, Korea / Seoul National University Boramae Hospital4, Seoul, Korea / Department of Ophthalmology, Chonnam National University Medical School & Hospital5, Gwangju, Korea / Department of Ophthalmology, College of Medicine, Pusan National University6, Pusan, Korea / Department of Ophthalmology, Konyang University, Kim's Eye Hospital7, Seoul, Korea / Department of Ophthalmology, Seoul National University College of Medicine8, Seoul, Korea |
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| Abstract |
PURPOSE
To prospectively investigate the change of clinical manifestations after 1 year of administration of anthocyanoside (Tagen-F(R)) to patients with NPDR-associated macular edema. METHODS: One hundred seventy-five eyes in 88 patients were enrolled in this study, at 5 centers, from March, 2005 to October, 2005. Patients took 3 capsules of Vaccinium myrtillus extract (170 mg/capsule, Tagen-F(R), Kukje pharmaceutical) per day. The primary endpoints were corrected visual acuity and contrast sensitivity which were checked at 2 months following the beginning of treatment [East 1]. The secondary endpoints were the number of hard exudates, microaneurysms, leaking points and the changes of foveal thickness. These were examined at the beginning of, 6 months after, and 12 months after treatment. RESULTS: Corrected visual acuity showed no significant changes during 12 months. Contrast sensitivity improved gradually, especially in 12, 16 cycles per degree [East 2]. There was no statistically significant changes in the numbers of hard exudates, microaneurysms, and leaking points. Foveal thickness measured by OCT was maintained and there was no aggravation of macular edema. CONCLUSIONS: There was marked improvement of contrast sensitivity in patients with NPDR after 1 year of administration of anthocyanoside (Tagen-F(R)), and it might contribute to the quality of vision and the satisfaction of patients. Visual acuity and macular edema were maintained without aggravation. |
| Key Words:
Anthocyanoside;Diabetic retinopathy;Macular edema |
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