J Korean Ophthalmol Soc > Volume 49(10); 2008 > Article
Journal of the Korean Ophthalmological Society 2008;49(10):1649-1657.
DOI: https://doi.org/10.3341/jkos.2008.49.10.1649    Published online October 15, 2008.
The Antimydriatic Effect of Brimonidine 0.15% on the Dark-adapted Pupil in Dark Brown Irides.
Seung Soo Rho, Hong Seok Yang, Ho Min Lew, Jae Hong Ahn
Department of Ophthalmology, Ajou University School of Medicine, Suwon, Korea. chrisahn@ajou.ac.kr
갈색홍채에서 브리모니딘 0.15%의 야간 항산동 효과
노승수ㆍ양홍석ㆍ유호민ㆍ안재홍
Department of Ophthalmology, Ajou University School of Medicine, Suwon, Korea
Abstract
PURPOSE
To analyze the effect of the daily use of brimonidine tartrate 0.15% on the dark-adapted pupil diameter in dark brown irides. METHODS: Twenty-five healthy volunteers administered brimonidine tartrate 0.15% to their right eyes once daily for 3 weeks. Infrared digital photographs of the pupil were taken before administration and 1 hour and 4 hours after administration after dark adaptation (at <0.1 lux ambient illumination for 5 minutes). The diameters of both pupils were measured on the first day, on administration days 7 and 21, and on washout day 7. RESULTS: Four hours after the first administration, pupils showed a decrease of 0.95+/-0.74 mm, 1.03+/-0.94 mm, 0.61+/-0.85 mm on the first day, administration day 7, and administration day 21, respectively (p<0.01), compared with baseline data. The anti-mydriatic effect of brimonidine was sustained for 3 weeks, but the proportions of the eyes showing a reduction in pupil diameter by 0.5 mm or more were 84%, 76%, 68%, and 52% at 4 hours on the first day, administration days 7 and 21, and washout day 7, respectively. CONCLUSIONS: The anti-mydriatic effect of the daily use of brimonidine 0.15% on dark brown irides in a scotopic condition is maintained during the instillation period but has a tendency to fade over time. This point should be considered when using this compound as a miotic agent.
Key Words: Anti-mydriatic effect;Brimonidine tartrate 0.15%;Brown iris;Dark-adapted pupil
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