A Case of Fungal Keratitis Treated with Voriconazole.

Yoon, Jong Uk; Kim, Sang Woo; Ha, Byoung Jin; Kim, Tae im; Kim, Eung Kweon

doi:2008.49.10.1680

J Korean Ophthalmol Soc > Volume 49(10); 2008 > Article

Case Report

Journal of the Korean Ophthalmological Society 2008;49(10):1680-1684.
DOI: https://doi.org/10.3341/jkos.2008.49.10.1680 Published online October 15, 2008.

A Case of Fungal Keratitis Treated with Voriconazole.

Jong Uk Yoon, Sang Woo Kim, Byoung Jin Ha, Tae im Kim, Eung Kweon Kim

The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea. tikim@yuhs.ac

라섹 후 발생한 진균성 각막염에서 보리코나졸을 이용한 치료 1예

윤종억ㆍ김상우ㆍ하병진ㆍ김태임ㆍ김응권

The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea

Abstract

PURPOSE
To report drug-resistant fungal keratitis that was treated with voriconazole. CASE SUMMARY: A 31-year-old man was admitted to hospital because of ocular pain, conjunctival injection, and visual weakness 7 days after LASIK surgery. At that time, his vision was counting finger at 30 cm and he presented with corneal epithelial defects, stromal infiltration, and inflammation in the anterior chamber of his eye. He was transferred to our hospital because his infection was resistant to gatifloxacin, tobramycin, amphotericin B, and natamycin eyedrops. At the time of transfer, his vision was counting finger at 30 cm and he presented with corneal epithelial defects, stromal infiltration, and hypopyon. He was treated with topical 2% voriconazole every 2 hours and the lesion improved. However, the hypopyon recurred after 12 days. He was then treated with intracameral voriconazole injection (50 microgram/0.1 cc) and topical 5% voriconazole every hour causing the hypopyon to disappear. His vision improved from counting finger to 20/40 six months after this treatment.

Key Words: Fungal keratitis;LASEK;Pseudoallescheria boydii;Voriconazole