Journal of the Korean Ophthalmological Society 2005;46(6):1052-1059.
Published online June 30, 2005.
Inhibitory Effect of Rapamycin on Corneal Neovascularization induced by Angiogenin in Rabbits.
Young Sam Kwon, Soo Ik Chang, Dong Ku Kang, Jae Chan Kim
1Department of Ophthalmology, Chung-Ang University, College of Medicine, Seoul, Korea.
2Department of Biochemistry, Chungbuk National University, College of Natural Science, Chungju, Korea. jck50ey@kornet.net
엔지오제닌에 의한 가토 각막 혈관신생에 대한 라파마이신의 억제 효과
권영삼1,장수익2,강동구2,김재찬1
Department of Ophthalmology, Chung-Ang University, College of Medicine1, Seoul, Korea Department of Biochemistry, Chungbuk National University, College of Natural Science2, Chungju, Korea
Correspondence:  Young Sam Kwon, Ph.D.,1
Abstract
PURPOSE
The purpose of this study was to determine whether immunosuppressant, rapamycin could inhibit corneal angiogenesis induced by angiogenin and to evalutate its role by micropocket assay. METHODS: The rabbit's eye was implanted intrastromally into the superior cornea with pellet for the control group, pellet containing of angiogenin for the angiogenin group, and pellet containing of angiogenin and rapamycin for the angiogenin+rapamycin group. Biomicrographically, corneal angiogenesis was evaluated for 14 days after pellet implantation, based on the number and the length of new vessels. The neovascularized cornea also was examined histologically. RESULTS: We could observe that the angiogenin inducing corneal angiogenesis was inhibited by rapamycin. The score of neovascularization was significantly decreased in the angiogenin+rapamycin group than in the angiogenin group at 3, 7 and 10 days after pellet implantation (p<0.05). Histologically, the cornea of angiogenin+rapamycin group also showed much less new vessels than that of angiogenin group, in which inflammatory cells and edema was observed. CONCLUSIONS: Rapamycin appears to inhibit angiogenin induced angiogenesis in a rabbit corneal micropocket assay and may have therapeutic potential as an antiangiogenic agent.
Key Words: Angiogenin;Neovascularization;Rapamycin


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