Protein C and Protein S as a Risk Factor for Retinal Vein Occlusion.

Lee, Kyoung Seob; Chung, J K; Lee, Sung Jin

Original Article

Journal of the Korean Ophthalmological Society 2005;46(11):1796-1801.
Published online November 30, 2005.

Protein C and Protein S as a Risk Factor for Retinal Vein Occlusion.

Kyoung Seob Lee, J K Chung, Sung Jin Lee

¹ALC Eye Clinic, Seoul, Korea.
²Department of Ophthalmology, Soonchunhyang University College of Medicine, Seoul, Korea. wismile@unitel.co.kr

망막정맥폐쇄의 위험인자로서 단백질 C와 단백질 S의 역할

이경섭¹,정진권²,이성진²

ALC Eye Clinic¹, Seoul, Korea Department of Ophthalmology, Soonchunhyang University College of Medicine², Seoul, Korea

Correspondence: Kyoung-Seob Lee, M.D.¹

Abstract

PURPOSE
The authors evaluated the possibility of protein C and protein S as risk factors for retinal vein occlusion (RVO). METHODS: We evaluated the medical histories and performed laboratory tests, including protein C and protein S, in patients who were diagnosed with RVO by fundus examination and fluorescein angiography. The same data were obtained from a healthy control group. We analyzed mean activity and the ratio of patients with decreased levels of protein C or protein S. RESULTS: Forty-seven patients with RVO in this study consisted of 14 with central retinal vein occlusion (CRVO) and 33 with branch retinal vein occlusion (BRVO). Sixteen normal subjects were also enrolled in this study as controls. There are no cases that presented decreased protein C activity. However, there was a statistically significant difference in the number of cases with protein S deficiency between the patients and the control group (p<0.05). CONCLUSIONS: Deficiency of anticoagulant proteins, especially protein S, may be a risk factor of retinal vein occlusion. Examination of the coagulation system may be useful in the systemic evaluation of RVO patients.

Key Words: Protein C;Protein S;Retinal vein occlusion