| Effect of Triamcinolone Acetonide on the Survival and Nitric Oxide Production in Cultured Human Tenon's Capsule Fibroblasts. |
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Hyo Won Lee, Jae Woo Kim |
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Department of Ophthalmology, Catholic University of Daegu College of Medicine, Daegu, Korea. jwkim@cu.ac.kr |
| 트리암시놀론이 배양된 사람 섬유아세포의 생존과 산화질소 생성에 미치는 영향 |
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이효원,김재우 |
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Department of Ophthalmology, Catholic University of Daegu College of Medicine, Daegu, Korea |
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Correspondence:
Hyo-Won Lee, M.D. |
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| Abstract |
PURPOSE
To investigate the effect of triamcinolone acetonide (TA) on cell survival and nitric oxide (NO) production in cultured human Tenon's capsule fibroblast (FB) cells. METHODS: After exposed to TA, indomethacin, and dexamethasone for 2 days, cell survival and nitrite production of primarily cultured human FB cells were assessed with MTT and Griess assays, respectively. RESULTS: Cell survival increased after exposure to TA at low concentrations but decreased at high concentrations. TA decreased the production of NO significantly (p<0.05). Exposure to indomethacin and dexamethasone revealed similar results. CONCLUSIONS: Both the biphasic effect on cell survival and the decreased production of NO induced by TA in FB cells could affect conjunctival wound healing. |
| Key Words:
Fibroblasts;Nitric oxide;Triamcinolone acetonide;Wound healing |
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