| The Relationship Between Ascorbic Acid Concentration of Anterior Chamber and Complication in Alkali-Injured Rabbit Eyes. |
|
Han Joo Cho, Jong Hyeok Lee |
|
Department of Ophthalmology, Wonju Christian Hospital Yonsei University, Wonju College of Medicine, Wonju, Korea. jhlee@wonju.yonsei.ac.kr |
| 가토 각막 알칼리 화상에서 전방내의 아스코르빈산 농도와 합병증 발생과의 관계 |
|
조한주,이종혁 |
|
Department of Ophthalmology, Wonju Christian Hospital Yonsei University, Wonju College of Medicine, Wonju, Korea |
|
Correspondence:
Han-Joo Cho, M.D. |
|
|
| Abstract |
PURPOSE
To study the relationship between the concentration of ascorbic acid in the anterior chamber and the complications of an experimental alkali burn in rabbit corneas. METHODS: Standardized corneal alkali wounds were induced in both eyes of 33 albino rabbits by applying a 5.5 mm-sized round filter paper, soaked in 1N NaOH for 20 seconds. Then, the control group (22 eyes) was given Tears Natural II(R) (Alcon), treated group A (22 eyes) was given ascorbic acid (10%) for 2 hours, and treated group B (22 eyes) was given ascorbic acid (10%) for 6 hours. The concentrations of ascorbic acid in the anterior chamber were measured using a microplate assay immediately post-injury, and at 5 days, 15 days, and 30 days post-injury. During the experiment, clinical observation was performed to detect complications such as corneal ulcer or perforation. RESULTS: The incidence of ulceration was significantly lower between control group and treated groups A and B (p<0.05). The incidence of perforation was significantly lower in treated group A compared to the control group B (p<0.05). In addition, a higher concentration of ascorbic acid in the anterior chamber and a lower severity of corneal injury was significant (sigma=-0.302, P<0.05). CONCLUSIONS: Higher concentrations of ascorbic acid in the anterior chamber were associated with fewer complications in experimental alkali burns in rabbit corneas. |
| Key Words:
Alkali burn;Anterior chamber;Ascorbic acid |
|
PDF Links
Download Citation
