A Case of Cancer-Associated Retinopathy with Small Cell Lung Cancer.

Yang, Sun Mo; Oh, In Kyung; Oh, Jae Ryung; Huh, Kuhl

Case Report

Journal of the Korean Ophthalmological Society 2006;47(7):1171-1176.
Published online July 31, 2006.

A Case of Cancer-Associated Retinopathy with Small Cell Lung Cancer.

Sun Mo Yang, In Kyung Oh, Jae Ryung Oh, Kuhl Huh

Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea. ojr4991@yahoo.co.kr

폐암 환자에서 발생한 암관련망막병증 1예

양선모,오인경,오재령,허걸

Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea

Correspondence: Sun Mo Yang, M.D.

Abstract

PURPOSE
To report a case of cancer-associated retinopathy developed in a patient with small cell lung cancer, which is a kind of paraneoplastic syndrome. METHODS: A 78-year-old woman presented complaining of decreased visual acuity and visual field that had developed about 15 days previously. She was diagnosed with small cell lung cancer 1.5 years ago and underwent 3 cycles of chemotherapy. At presentation, the best-corrected visual acuity was hand motion in both eyes and there was no afferent pupillary defect. Slit-lamp biomicroscopic examination revealed no specific abnormality in the anterior segment of either eye, and intraocular pressure was normal. Posterior segment examination demonstrated remarkable arteriolar narrowing in both eyes, but there was little doubt about the presence of an optic nerve lesion such as optic disc edema or pallor. RESULTS: Fluorescein angiography and brain magnetic resonance imaging (MRI) revealed no significant abnormalities. However, electroretinograms (ERG) demonstrated marked reduction in the a and b waves. Visual evoked response was delayed for the latency period. She was treated with systemic steroid, after which her visual acuity gradually improved.

Key Words: Arteriolar narrowing;Cancer-associated retinopathy;ERG;Paraneoplastic syndrome;Small cell lung cancer