| The Clinical Phenotype of Thyroid-Associated Orbitopathy related to Underlying Thyroid Status. |
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Dong Ah Ko, Byoung Jin Kim, Michael Kazim |
1Department of Ophthalmology, Kangdong Sacred Heart Hospital, Hallym University, College of Medicine, Seoul, Korea. feeloph@naver.com
2Department of Ophthalmology, New York Presbyterian Hospital, Columbia University, College of Physicians and Surgeons, New York, U.S.A. |
| 갑상샘기능에 따른 갑상샘연관안와병증의 임상양상 |
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고동아1,김병진1,Michael Kazim2 |
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Department of Ophthalmology, Kangdong Sacred Heart Hospital, Hallym University, College of Medicine1, Seoul, Korea Department of Ophthalmology, New York Presbyterian Hospital, Columbia University, College of Physicians and Surgeons2, New York, U.S.A. |
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Correspondence:
Dong Ah Ko, M.D.1 |
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| Abstract |
PURPOSE
Thyroid-Associated Orbitopathy (TAO) presents with highly variable clinical characteristics. We hypothesize that the underlying thyroid status predisposes a patient to different clinical characteristics of TAO. METHODS: We retrospectively studied the clinical data of 385 patients from the New York area who were referred to our clinic and diagnosed with TAO from Jan 1990 to Dec 2000. We divided the 385 patients into three groups: Graves' hyperthyroid, euthyroid, and hypothyroid, and analyzed them statistically. RESULTS: Three hundred thirty-one (86%) patients were hyperthyroid, 25 (6.5%) were euthyroid, and 29 (7.5%) were hypothyroid. The average age of TAO presentation in each group was 46.7, 46.1, and 49.9 years, respectively. The female-male ratio in each group was 5.25, 3.17, 13.5:1, respectively (p>0.05). The average time from thyroid disease to TAO in the hyperthyroid and hypothyroid groups was 16.6 and 38 months, respectively (p<0.05). The hyperthyroid group had more proptosis (76.1 vs. 41.4%, p=0.0001<0.05) than the hypothyroid group. CONCLUSIONS: TAO has different clinical characteristics depending on thyroid status. The hyperthyroid group has a short disease interval and more severe clinical course of TAO than the hypothyroid group. |
| Key Words:
Thyroid-Associated Orbitopathy (TAO);Variable clinical characteristic |
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