| Nerve Growth Factor Concentration and Implications in Photorefractive Keratectomy Versus Laser in Situ Keratomileusis. |
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Won Kyung Song, Hyung Keun Lee, Hyeon Chang Kim, Sung Ho Lee, Eung Kwon Kim |
1Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea. shadik@yumc.yonsei.ac.kr
2Department of Preventive Medicine and Public Health, Yonsei University College of Medicine, Seoul, Korea.
3Benebiosis Laboratory, Seoul, Korea. |
| 굴절교정레이저각막절제술과 레이저각막절삭성형술에서 신경성장인자의 농도와 의미 |
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송원경1,이형근1,김현창2,이성호3,김응권1 |
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Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine1, Seoul, Korea Department of Preventive Medicine and Public Health, Yonsei University College of Medicine2, Seoul, Korea Benebiosis Laboratory3, Seoul, Korea |
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Correspondence:
Won Kyung Song, M.D.1 |
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| Abstract |
PURPOSE
To determine whether tear nerve growth factor (NGF) concentration correlates with corneal sensation and ocular surface dryness after photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK). METHODS: A prospective, non-randomized comparative clinical trial. Seventy eyes of 35 patients and 76 eyes of 38 patients underwent PRK and LASIK procedures to correct myopia and myopic astigmatism, respectively. Total tear protein level, tear NGF concentration, corneal sensation, tear film break-up time (BUT) and Schirmer values were measured before and 1 day, 1 week, 1 month, 3 months, and 6 months after the surgery. RESULTS: The postoperative mean tear NGF/total tear protein ratio (NGF/tP) increased in both PRK and LASIK patients compared to their preoperative levels (p<0.0001). At 1 week and 1 month postoperatively, the NGF/tP ratio was higher in PRK than in LASIK subjects (p<0.0001). Up to 6 months postoperatively, the mean corneal sensation after LASIK in the ablated zone was lower than the preoperative sensation (p<0.0001), whereas this was not the case in PRK subjects. Mean BUT and Schirmer values were significantly lower in LASIK-treated eyes compared to PRK-treated eyes up to 6 months postoperatively (p<0.0001). The early postoperative tear NGF/tP ratio correlated with the postoperative 6 month corneal sensation, BUT and Schirmer values. CONCLUSIONS: The difference in postoperative corneal sensation and ocular surface dryness between PRK- and LASIK-treated eyes was related to the difference in the early postoperative levels of NGF/tP, which implies NGF might influence corneal nerve regeneration after these two surgeries. |
| Key Words:
Laser in situ keratomileusis (LASIK);Nerve growth factor (NGF);Photorefractive keratectomy (PRK);Schirmer test;Tear film break-up time (BUT) |
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