Journal of the Korean Ophthalmological Society 2006;47(9):1410-1416.
Published online September 30, 2006.
Photodynamic Therapy Results of Retinal Angiomatous Proliferation with Pigmented Epithelial Detachment in Age-related Macular Degeneration.
Suk Ho Byeon, Jin Pyo Hong, Hyo Lee, Sang Jun Oh, Sung Soo Kim, Hyoung Jun Koh, Sung Chul Lee, Oh Woong Kwon
1Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
2Department of Ophthalmology, Seoul Veterans Hospital, Seoul, Korea.
연령연관황반변성에서 망막혈관종성증식과 동반된 망막색소상피 박리의 임상양상과 일차적인 광역학치료의 결과
Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine1, Seoul, Korea Department of Ophthalmology, Seoul Veterans Hospital2, Seoul, Korea
Correspondence:  Suk Ho Byeon, M.D.1
To evaluate the incidence of retinal angiomatous proliferation (RAP) and retinal pigmented epithelial detachment (PED) in Korean age-related macular degeneration (ARMD) patients and results of photodynamic therapy (PDT) with verteporfin. METHODS: Between May 2001 and December 2004, two hundred fifty-eight patients diagnosed of ARMD were evaluated and nine eyes of seven patients were as having RAP with PED. All patients underwent two or more sessions of PDT. Best-corrected visual acuity (BCVA), fundus photography, fluorescein angiography and ICG angiography were performed before and after treatment. RESULTS: The incidence of RAP with PED was 2.8%. The mean age of onset was 71.7 and five of seven patients were female. After 17 months and mean 2.3 PDT treatments, mean BCVA decreased from 0.2 to 0.04. In two eyes, additional Transpupillary thermotherapy was undertaken. Occlusion of RAP and flattening of PED was observed in one eye, and four evolved toward stage 3 RAP. Three eyes with PDT developed tear of retinal pigmented epithelium. CONCLUSIONS: Korean ARMD patients showed a low incidence of RAP and poor visual outcomes even with treatment.
Key Words: Age-related macular degeneration (ARMD);Photodynamic therapy (PDT);Pigmented epithelial detachment (PED);Retinal angiomatous proliferation (RAP);Visual outcome;Neovascularization

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