Two Cases of Oculocerebrorenal Syndrome in Two Brothers Diagnosed after Congenital Cataract Surgery.

Suk, Kyung Won; Lee, Soo Jung; Kim, Wan Soo

Case Report

Journal of the Korean Ophthalmological Society 2006;47(9):1502-1511.
Published online September 30, 2006.

Two Cases of Oculocerebrorenal Syndrome in Two Brothers Diagnosed after Congenital Cataract Surgery.

Kyung Won Suk, Soo Jung Lee, Wan Soo Kim

¹Department of Ophthalmology, Maryknoll Hospital, Pusan, Korea. wansookim@yahoo.com
²Department of Ophthalmology, St. Mary's Medical Center, Pusan, Korea.

선천백내장으로 수술한 형제에서 진단된 안, 뇌, 신 증후군 2예

석경원¹,이수정^1,2,김완수^1,2

Department of Ophthalmology, Maryknoll Hospital¹, Pusan, Korea Department of Ophthalmology, St. Mary`s Medical Center², Pusan, Korea

Correspondence: Kyung Won Suk, M.D.¹

Abstract

PURPOSE
We report two cases of brothers diagnosed with oculocerebrorenal syndrome after binocular congenital cataract surgery. METHODS: Two brothers who had undergone surgeries for congenital cataracts showed growth retardation, proteinuria, and generalized tonic seizures. The patients were referred to the pediatrics department and evaluated for systemic diseases and genetic counseling. RESULTS: Two brothers had renal tubular dysfunction characterized by hypercalciuria and hyperphosphaturia. The older brother had multiple microcalcifications on both kidneys, and ischemic injury with general dysfunction of the brain. Genetic analysis of brothers and their mother showed a new mutation of P799L in the region of the chromosome Xq25-26.1 locus. The two brothers were diagnosed with oculocerebrorenal syndrome of Lowe (OCRL). CONCLUSIONS: In cases of patients with congenital cataracts, the evaluation of systemic disease including genetic abnormality should be considered whenever systemic symptoms such as growth retardation, proteinuria or seizure are found.

Key Words: Chromosome Xq25-26.1;Congenital cataracts;Oculocerebrorenal syndrome (OCRL)