| Topical 0.1% Prednisolone Lowers Nerve Growth Factor Expression in Keratoconjunctivitis Sicca Patients. |
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Seung Ah Chung, Hyung Keun Lee, Kyoung Yul Seo, Soon Won Hong, Hyung Chang Kim, Eung Kweon Kim |
1The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea. eungkkim@yumc.yonsei.ac.kr
2Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
3Department of Preventive Medicine and Public Health, Yonsei University College of Medicine, Seoul, Korea. |
| 건성각결막염 환자에서 스테로이드 점안 후 눈물 신경성장인자의 변화 |
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정승아1,이형근1,서경률1,홍순원2,김현창3,김응권1 |
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The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine1, Seoul, Korea Department of Pathology, Yonsei University College of Medicine2, Seoul, Korea Department of Preventive Medicine and Public Health, Yonsei University College of Medicine3, Seoul, Korea |
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Correspondence:
Seung Ah Chung, M.D.1 |
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| Abstract |
PURPOSE
To compare nerve growth factor (NGF) levels in tears and on the ocular surface of normal controls with those of non-Sjogren type keratoconjunctivitis sicca (KCS) subjects, and investigate the effect of 0.1% prednisolone eye drops on NGF levels in KCS patients. METHODS: Baseline tear NGF levels were measured in 41 KCS patients and 23 healthy control subjects using enzyme-linked immunosorbent assays (ELISA). KCS patients received 0.1% prednisolone drops in one eye, and 0.1% hyaluronic acid drops in the other eye, three times daily for 28 days. Impression cytology (IC) and immunostaining for NGF on conjunctival epithelium was performed for both groups. RESULTS: KCS patients were found to have higher baseline tear NGF concentrations compared to age- and sex-matched healthy control subjects (65.9+/-14.5 vs. 122.1+/-45.3, p<0.0001). In KCS patients, prednisolone treatment for 28 days resulted in a decrease in tear NGF levels, symptom scores and IC scores, whereas hyaluronic acid treatment had no such effect (68.2+/-25.0 pg/microgram vs. 108.0+/-43.4 pg/microgram, p<0.0001 for tear NGF/TP ratio; 2.16+/-1.01 vs. 3.39+/-1.50, p=0.0014 for symptom scale; 1.05+/-0.67 vs. 1.61+/-0.86, p=0.0317 for IC). Measurements taken at both 14 and 28 days indicate that neither prednisolone nor hyaluronic acid treatment affected BUT or Schirmer values. CONCLUSIONS: KCS patients showed elevated levels of tear NGF, which were decreased by treatment with 0.1% prednisolone. These data suggest that the ocular surface NGF may play an important role in ocular surface inflammation processes associated with dry eyes. |
| Key Words:
Keratoconjunctivitis sicca;Nerve growth factor;Prednisolone |
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