Effect of Disintegrin in Retina after Laser Photocoagulation.

Choi, Kyung Seek; Kim, Joon Soon; Park, Song Hee

Original Article

Journal of the Korean Ophthalmological Society 2006;47(11):1804-1810.
Published online November 30, 2006.

Effect of Disintegrin in Retina after Laser Photocoagulation.

Kyung Seek Choi, Joon Soon Kim, Song Hee Park

Department of Ophthalmology, Soonchunhyang University College of Medicine, Seoul, Korea. parksonghee55@hanmail.net

레이저조사 후 망막에서의 디스인테그린 효과

최경식,김준순,박성희

Department of Ophthalmology, Soonchunhyang University College of Medicine, Seoul, Korea

Correspondence: Kyung Seek Choi, M.D.

Abstract

PURPOSE
To investigate weather an administrated inhibitor (disintegrin) of angiogenic factors inhibits the development of laser-induced experimental choroidal neovascularization (CNV) in rat model. METHODS: Experimental CNV was induced by red argon laser photocoagulation in the eyes of 10 Brown Norway rats. The rats were divided into two groups, the disintegrin (flavoridin)-treated group and control group. Fundus photography and fluorescein angiography were performed to identify late leakage after two weeks of laser photocoagulation. Three days after fluorescein angiography, the expression of vascular endothelial growth factor (VEGF) was identified by immunohistochemical stain. RESULTS: CNV-related fluorescein leakage appeared in forty-four (18 in the flavoridin-treated group, 26 in the control group) of 64 laser spots delivered to the 10 eyes that were tested at two weeks post-treatment. Expression of VEGF on laser-induced CNV lesions was reduced in the flavoridin-treated group. CONCLUSIONS: The results of this study suggest that disintegrin is an inhibitor of ocular angiogenesis; disintegrin reduced CNV in laser-induced experimental model. We expect that disintegrin may have a potent effect in age-related macular degeneration.

Key Words: Choroidal neovascularization;Disintegrin;Vascular endothelial growth factor