Clinical Effects of Various Antiinflammatory Therapies in Dry Eye Syndrome.

Her, Jun; Yu, Sun Im; Seo, Sung Gwan

Original Article

Journal of the Korean Ophthalmological Society 2006;47(12):1901-1910.
Published online December 31, 2006.

Clinical Effects of Various Antiinflammatory Therapies in Dry Eye Syndrome.

Jun Her, Sun Im Yu, Sung Gwan Seo

Department of Ophthalmology Pusan Paik Hospital Inje University College of Medicine, Pusan, Korea. hereye@inje.ac.kr

건성안 환자에서 다양한 항염증 치료에 따른 임상효과

허준,유선임,서성관

Department of Ophthalmology Pusan Paik Hospital Inje University College of Medicine, Pusan, Korea

Correspondence: Jun Her, M.D.

Abstract

PURPOSE
To evaluate the therapeutic effect of cyclosporin A, corticosteroid, autologous serum in patients with severe dry eye syndrome. METHODS: Patients (72 eyes) with severe dry eye syndrome were classified into four groups were treated for 3 months. Each group was treated with 0.05% cyclosporin A, 1% rimexolone, 20% autologous serum, and artificial tears. Before and after treatment (2, 4, 8, 12 weeks), Ocular Surface Disease Index (OSDI), tear film break-up time (BUT), Schirmer test, corneal sensitivity, and lissamine green staining score were measured. RESULTS: After treatment, OSDI, tear film BUT, Schirmer test, corneal sensitivity, and the lissamine green staining score were improved in groups using cyclosporin A, autologous serum and corticosteroid(p<0.05), but clinical effects did not improve in the group using artificial tears except for corneal sensitivity (p>0.05). CONCLUSIONS: Antiinflammatory theraphy is more effective than the conventional symptomatic theraphy in patients with severe dry eye syndrome.

Key Words: Antiinflammatory theraphy;Autologous serum;Corticosteroid;Cyclosporin A;Dry eye syndrome