A Report of Localized Corneal Amyloidosis Secondary to the Trichiasis.

Kim, Jee Taek; Kim, Eun Young; Lee, Hyeon Il; Chun, Yeoun Sook; Song, Gae Young; Kim, Jae Chan

Case Report

Journal of the Korean Ophthalmological Society 2006;47(12):2035-2040.
Published online December 31, 2006.

A Report of Localized Corneal Amyloidosis Secondary to the Trichiasis.

Jee Taek Kim, Eun Young Kim, Hyeon Il Lee, Yeoun Sook Chun, Gae Young Song, Jae Chan Kim

¹Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul, Korea. jck50ey@kornet.net
²Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
³Department of Pathology, Chung-Ang University College of Medicine, Seoul, Korea.

속눈썹증에 의한 각막 아밀로이드증에 대한 보고

김지택¹,김은영²,이헌일¹,전연숙¹,송계용³,김재찬¹

Department of Ophthalmology¹, Department of Internal Medicine², Department of Pathology³ Chung-Ang University College of Medicine, Seoul, Korea

Correspondence: Jee Taek Kim, M.D.¹

Abstract

PURPOSE
To report our experience in the diagnosis and treatment of a localized corneal amyloidosis secondary to trichiasis. METHODS: Case 1. A 55-year-old woman visited our clinic due to discomfort of her right eye. Thirty years previously, she received a lower lid blepharoplasty due to lower lid entropion. Biomicroscopy revealed some trichiasis and a 3 mm, grayish-white nodule at the center of the cornea. Case 2. A 30-year-old woman visited our clinic due to chronic irritation of both eyes. Ten and 3 years previously, she received a lower lid blepharoplasty. Biomicroscopy revealed some trichiasis of the right lower lid and a grayish-white, patch-like lesion at the inferior cornea of both eyes. Lamellar keratectomy and amniotic membrane transplantation with careful electrolysis were performed. RESULTS: Hematoxylin and eosin stain revealed a pink, amorphous, hyaline material under the epithelium, and Congo-red stain showed birefringence of the whitish lesion. Electron microscopy revealed multidirectional, fibrillar arrangement. Secondary, localized amyloidosis of the cornea was diagnosed without any systemic involvement. No clues to the origin of the amyloid were found by immunohistochemical staining. By the sixth month after operation, the patients showed favorable vision and no evidence of recurrence. CONCLUSIONS: In the identification of a corneal mass, a secondary, localized amyloidosis should be considered, which can be managed successfully.

Key Words: Amyloidosis;Cornea;Trichiasis