The Usefulness of the Uniocular Drug Trial in the Glaucoma Eyes.

Shin, Hyung Ho; Yoo, Chung Kwon; Choi, Young Jae; Kim, Yong Yeon

Original Article

Journal of the Korean Ophthalmological Society 2007;48(1):91-96.
Published online January 31, 2007.

The Usefulness of the Uniocular Drug Trial in the Glaucoma Eyes.

Hyung Ho Shin, Chung Kwon Yoo, Young Jae Choi, Yong Yeon Kim

Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea. yongykim@mail.korea.ac.kr

녹내장안에서 단안 약물치료 시도의 효용성

신형호,유정권,최영재,김용연

Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea

Correspondence: Hyung Ho Shin, M.D.

Abstract

PURPOSE
This study was undertaken to evaluate if the reduction of intraocular pressure (IOP) observed in a uniocular trial correlates with an IOP reduction observed in the fellow eye. METHODS: The study was performed on forty patients with bilateral glaucoma or suspect glaucoma who underwent a uniocular trial of 0.005% latanoprost and subsequently received the same drug in the fellow eye after 1 week. Inter-eye IOP variations were less than 3 mm Hg over two measurements, and were followed minimally for 4 weeks. The uniocular IOP reduction (IOP before medication - IOP after medication) and the net IOP reduction (IOP change in the trial eye after medication - IOP change in the fellow eye) were calculated. The uniocular IOP reduction and net IOP reduction in the trial eye was compared with the results from the fellow eye. RESULTS: The mean uniocular IOP reduction in the trial eye and the fellow eye were 3.6+/-2.42 mm Hg and 2.78+/-2.16 mm Hg, respectively (r=0.390, r2=0.152, P=0.013). The mean net IOP reduction in the trial eye and the opposing eye were 3.55+/-1.70 mm Hg and 3.15+/-1.83 mm Hg, respectively (r=0.782, r2=0.612, P=0.000). CONCLUSIONS: A uniocular drug trial in patients with similar IOPs between their eyes can adequately predict the IOP lowering effect of a medication.

Key Words: Net IOP reduction;Uniocular drug trial;Uniocular IOP reduction